KL-Biome (Postbiotic Formulation of Lactiplantibacillus plantarum KM2) Improves Dexamethasone-Induced Muscle Atrophy in Mice.

Autor: Jeong YJ; Department of Foods and Nutrition, Kookmin University, Seoul 02707, Republic of Korea., Kim JH; KookminBio Corporation, Seoul 02826, Republic of Korea., Jung YJ; KookminBio Corporation, Seoul 02826, Republic of Korea., Kwak MS; KookminBio Corporation, Seoul 02826, Republic of Korea., Sung MH; KookminBio Corporation, Seoul 02826, Republic of Korea., Imm JY; Department of Foods and Nutrition, Kookmin University, Seoul 02707, Republic of Korea.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 08; Vol. 25 (13). Date of Electronic Publication: 2024 Jul 08.
DOI: 10.3390/ijms25137499
Abstrakt: Sarcopenia refers to an age-related decrease in muscle mass and strength. The gut-muscle axis has been proposed as a promising target to alleviate muscle atrophy. The effect of KL-Biome-a postbiotic preparation comprising heat-killed Lactiplantibacillus plantarum KM-2, its metabolites, and an excipient (soybean powder)-on muscle atrophy was evaluated using dexamethasone (DEX)-induced atrophic C2C12 myoblasts and C57BL/6J mice. KL-Biome significantly downregulated the expression of genes (Atrogin-1 and MuRF1) associated with skeletal muscle degradation but increased the anabolic phosphorylation of FoxO3a, Akt, and mTOR in C2C12 cells. Oral administration of KL-Biome (900 mg/kg) for 8 weeks significantly improved muscle mass, muscle function, and serum lactate dehydrogenase levels in DEX-treated mice. KL-Biome administration increased gut microbiome diversity and reversed DEX-mediated gut microbiota alterations. Furthermore, it significantly increased the relative abundances of the genera Subdologranulum , Alistipes , and Faecalibacterium prausnitzii , which are substantially involved in short-chain fatty acid production. These findings suggest that KL-Biome exerts beneficial effects on muscle atrophy by regulating gut microbiota.
Databáze: MEDLINE
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