Paradoxical Psoriasis in Patients Receiving Therapy with Tumor Necrosis Factor Inhibitors: Potential Pathogenic Mechanisms and the Role of Genetic Factors.

Autor:	Costin D; Department of Medical Sciences II, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Burlui AM; Department of Medical Sciences II, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Cardoneanu A; Department of Medical Sciences II, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Macovei LA; Department of Medical Sciences II, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Rezus C; Department of Internal Medicine, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; 'Sfantul Spiridon' Emergency Hospital, 700111 Iasi, Romania., Bratoiu I; Department of Medical Sciences II, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Richter P; Department of Medical Sciences II, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Mihai IR; Department of Medical Sciences II, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania., Gherasim A; Department of Medical Sciences II, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; 'Sfantul Spiridon' Emergency Hospital, 700111 Iasi, Romania., Danielescu C; Department of Surgery II, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; 'Profesor Dr. Nicolae Oblu' Clinical Emergency Hospital, 700309 Iasi, Romania., Rezus E; Department of Medical Sciences II, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Clinical Rehabilitation Hospital, 700661 Iasi, Romania.
Jazyk:	angličtina
Zdroj:	International journal of molecular sciences [Int J Mol Sci] 2024 Jun 27; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 27.
DOI:	10.3390/ijms25137018
Abstrakt:	TNF inhibitors (TNFi) have revolutionized the therapeutic management of various chronic immune-mediated inflammatory diseases. Despite their known benefits, these therapies are related to paradoxical adverse effects (PAEs), including paradoxical psoriasis (PP). Although the underlying mechanism remains somewhat unclear, some theories suggest that genetic factors, particularly certain single-nucleotide polymorphisms (SNPs), may play an important role. The present review aimed to research and analyze recent findings regarding the pathomechanisms involved in the appearance of PP and the association between various genetic factors and PP in individuals treated with TNFi. We performed a literature search and found that certain genes (IL23R , TNF , FBXL19 , CTLA4 , SLC12A8 , TAP1 ) are strongly associated with the occurrence of PP in pediatric and adult patients during therapy with TNFi. The identification of the specific SNPs involved in the appearance of PP and other PAEs in patients treated with TNFi for various diseases and in different populations may later favor the recognition of those patients at a high risk of developing such adverse effects and could guide personalized therapeutic strategies in future years.
Databáze:	MEDLINE
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