| Autor: |
Currie C; Hofseth BioCare, Keiser Wilhelms Gate 24, 6003 Alesund, Norway., Myklebust TÅ; Department of Research and Innovation, More og Romsdal Hospital Trust, 6026 Ålesund, Norway.; Department of Registration, Cancer Registry of Norway, 0379 Oslo, Norway., Bjerknes C; Hofseth BioCare, Keiser Wilhelms Gate 24, 6003 Alesund, Norway., Framroze B; Hofseth BioCare, Keiser Wilhelms Gate 24, 6003 Alesund, Norway. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of molecular sciences [Int J Mol Sci] 2024 Jun 24; Vol. 25 (13). Date of Electronic Publication: 2024 Jun 24. |
| DOI: |
10.3390/ijms25136917 |
| Abstrakt: |
Cytokines, chemokines, and interferons are released in response to viral infection with the ultimate aim of viral clearance. However, in SARS-CoV-2 infection, there is an imbalanced immune response, with raised cytokine levels but only a limited interferon response with inefficient viral clearance. Furthermore, the inflammatory response can be exaggerated, which risks both acute and chronic sequelae. Several observational studies have suggested a reduced risk of progression to severe COVID-19 in subjects with a higher omega-3 index. However, randomized studies of omega-3 supplementation have failed to replicate this benefit. Omega-3 fats provide important anti-inflammatory effects; however, fatty fish contains many other fatty acids that provide health benefits distinct from omega-3. Therefore, the immune health benefit of whole salmon oil (SO) was assessed in adults with mild to moderate COVID-19. Eleven subjects were randomized to best supportive care (BSC) with or without a full spectrum, enzymatically liberated SO, dosed at 4g daily, for twenty-eight days. Nasal swabs were taken to measure the change in gene expression of markers of immune response and showed that the SO provided both broad inflammation-resolving effects and improved interferon response. The results also suggest improved lung barrier function and enhanced immune memory, although the clinical relevance needs to be assessed in longer-duration studies. In conclusion, the salmon oil was well tolerated and provided broad inflammation-resolving effects, indicating a potential to enhance immune health. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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