Incidence of Subclinical Deep Vein Thrombosis after Total Hip and Knee Arthroplasty Is Not Correlated with Number of Tranexamic Acid Doses.

Autor:	Bocea BA; Faculty of Medicine Sibiu, Lucian Blaga University, Str. Lucian Blaga Nr. 2A, 550169 Sibiu, Romania.; County Clinical Emergency Hospital, 550245 Sibiu, Romania., Catrina BI; Faculty of Medicine Sibiu, Lucian Blaga University, Str. Lucian Blaga Nr. 2A, 550169 Sibiu, Romania.; County Clinical Emergency Hospital, 550245 Sibiu, Romania., Roman MD; Faculty of Medicine Sibiu, Lucian Blaga University, Str. Lucian Blaga Nr. 2A, 550169 Sibiu, Romania.; County Clinical Emergency Hospital, 550245 Sibiu, Romania., Ion NCI; Faculty of Medicine Sibiu, Lucian Blaga University, Str. Lucian Blaga Nr. 2A, 550169 Sibiu, Romania.; County Clinical Emergency Hospital, 550245 Sibiu, Romania., Fleaca SR; Faculty of Medicine Sibiu, Lucian Blaga University, Str. Lucian Blaga Nr. 2A, 550169 Sibiu, Romania.; County Clinical Emergency Hospital, 550245 Sibiu, Romania., Mohor CI; Faculty of Medicine Sibiu, Lucian Blaga University, Str. Lucian Blaga Nr. 2A, 550169 Sibiu, Romania.; County Clinical Emergency Hospital, 550245 Sibiu, Romania., Raluca AO; Faculty of Medicine Sibiu, Lucian Blaga University, Str. Lucian Blaga Nr. 2A, 550169 Sibiu, Romania.; County Clinical Emergency Hospital, 550245 Sibiu, Romania., Moga SI; County Clinical Emergency Hospital, 550245 Sibiu, Romania., Mihaila RG; Faculty of Medicine Sibiu, Lucian Blaga University, Str. Lucian Blaga Nr. 2A, 550169 Sibiu, Romania.; County Clinical Emergency Hospital, 550245 Sibiu, Romania.
Jazyk:	angličtina
Zdroj:	Journal of clinical medicine [J Clin Med] 2024 Jun 29; Vol. 13 (13). Date of Electronic Publication: 2024 Jun 29.
DOI:	10.3390/jcm13133834
Abstrakt:	Background: Recent studies increasingly highlight the efficacy of tranexamic acid administration in total hip arthroplasty (THA) and total knee arthroplasty (TKA). However, the optimal dosage of tranexamic acid is still controversial. Methods: The current study analyzes the efficiency of tranexamic acid dosage and the number of administrations in THA and TKA. The objective of this study is to compare the incidence of deep vein thrombosis (DVT) based on the number of dosages. We divided the patients into two groups; one group received a single dosage, and the other group received two dosages. Doppler ultrasound examinations were conducted on the lower limbs of all patients at both six and thirty days postoperatively. The second objective is to compare the decrease in hemoglobin (Hb) in the two groups. Results: The results show that there is no difference in DVT incidence between the patients with different TXA numbers of dosages. There is no statistically significant decrease in Hb between the two groups at day one and day five postoperatively. Day one shows a statistically higher average in the two-dose group, approximately 0.06 g/dL, and day five shows a slightly elevated average in the single-dose group, approximately 0.06 g/dL. Blood transfusion requirements show no significant differences in the groups; one patient in the single-dose tranexamic acid group needed transfusion at day five postoperatively, while two patients in each group required immediate postoperative transfusion. Conclusion: There was no increase in the incidence of deep vein thrombosis among patients receiving two dosages of tranexamic acid.
Databáze:	MEDLINE
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