Clostridioides difficile Infection in the Elderly: Trend Analysis from 2000 to 2019.

Autor: Danpanichkul P; Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.; Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand., Duangsonk K; Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand., Uawithya E; Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand., Kongarin S; Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand., Simadibrata DM; Faculty of Medicine, Universitas Indonesia, Depok 16424, Indonesia.; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA., Polpichai N; Department of Internal Medicine, Weiss Memorial Hospital, Chicago, IL 60640, USA., Suenghataiphorn T; Department of Internal Medicine, Griffin Hospital, Derby, CT 06460, USA., Wattanachayakul P; Department of Medicine, Albert Einstein Healthcare Network, Philadelphia, PA 19144, USA., Pang Y; Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China.; National Immunological Laboratory for Traditional Chinese Medicine, Baise 533000, Guangxi, China., Sukphutanan B; Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand., Kaewdech A; Gastroenterology and Hepatology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand., Panpradist N; Global Center for Integrated Health for Women, Adolescents, and Children (Global WACh), Department of Global Health, University of Washington, Seattle, WA 98195, USA., Chaiyakunapruk N; Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA.; IDEAS Center, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, UT 84148, USA., Pupaibool J; Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84113, USA., Wijarnpreecha K; Division of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Phoenix, AZ 85004, USA.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Banner University Medical Center, Phoenix, AZ 85724, USA.; BIO5 Institute, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2024 Jun 26; Vol. 13 (13). Date of Electronic Publication: 2024 Jun 26.
DOI: 10.3390/jcm13133740
Abstrakt: Background/Objective : Clostridioides difficile infection (CDI) is a common healthcare-associated ailment, presenting major health and economic challenges, especially for the elderly. Despite its prevalence, comprehensive data about CDI's impact on the elderly are limited. Methods : This study used the Global Burden of Disease Study 2019 data to analyze CDI trends from 2000 to 2019, considering factors like sex, region, and sociodemographic index (SDI). Results : This study revealed that CDI caused approximately 18,181 deaths and 252,709 disability-adjusted life years (DALYs) among the elderly worldwide. The Americas showed the highest CDI burden, while the Eastern Mediterranean saw the steepest rate increase from 2000 to 2019. Regions with a high SDI also displayed substantial CDI impact. Conclusions : The escalating burden of CDI in the elderly, especially in high-SDI areas and the Americas, emphasizes an urgent need for targeted public health strategies.
Databáze: MEDLINE