Phage Display Technology in Biomarker Identification with Emphasis on Non-Cancerous Diseases.

Autor: Sadraeian M; Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW 2007, Australia., Maleki R; Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia., Moraghebi M; Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia., Bahrami A; Department of Chemistry and Biochemistry, Bioengineering, and Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2024 Jun 25; Vol. 29 (13). Date of Electronic Publication: 2024 Jun 25.
DOI: 10.3390/molecules29133002
Abstrakt: In recent years, phage display technology has become vital in clinical research. It helps create antibodies that can specifically bind to complex antigens, which is crucial for identifying biomarkers and improving diagnostics and treatments. However, existing reviews often overlook its importance in areas outside cancer research. This review aims to fill that gap by explaining the basics of phage display and its applications in detecting and treating various non-cancerous diseases. We focus especially on its role in degenerative diseases, inflammatory and autoimmune diseases, and chronic non-communicable diseases, showing how it is changing the way we diagnose and treat illnesses. By highlighting important discoveries and future possibilities, we hope to emphasize the significance of phage display in modern healthcare.
Databáze: MEDLINE