COVID-19 vaccination-induced antibody responses and waning by age and comorbidity status in a large population-based prospective cohort study.

Autor: Hoeve CE; National Institute for Public Health and the Environment, the Netherlands. Electronic address: Christel.hoeve@rivm.nl., Huiberts AJ; National Institute for Public Health and the Environment, the Netherlands., de Gier B; National Institute for Public Health and the Environment, the Netherlands., Andeweg SP; National Institute for Public Health and the Environment, the Netherlands., den Hartog G; National Institute for Public Health and the Environment, the Netherlands., de Melker HE; National Institute for Public Health and the Environment, the Netherlands., Hahne SJM; National Institute for Public Health and the Environment, the Netherlands., van de Wijgert JHHM; National Institute for Public Health and the Environment, the Netherlands., van den Hof S; National Institute for Public Health and the Environment, the Netherlands., Knol MJ; National Institute for Public Health and the Environment, the Netherlands.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Nov 14; Vol. 42 (25), pp. 126121. Date of Electronic Publication: 2024 Jul 14.
DOI: 10.1016/j.vaccine.2024.07.022
Abstrakt: Background: Information on the magnitude and duration of antibody levels after COVID-19 vaccination in different groups may be useful for prioritizing of additional vaccinations.
Methods: Serum samples were collected every six months in a prospective cohort study among adults in the Netherlands. Geometric mean concentrations (GMCs) of antibodies against the receptor binding domain of the SARS-CoV-2 spike protein were calculated after the primary series, first, and second booster vaccinations. Effects of age (18-59 vs 60-85 years) and medical risk conditions on GMC 2-6 weeks and 21-25 weeks after each vaccination, and on waning during 3-25 weeks after each vaccination, were estimated by linear regression.
Results: We included 20,640, 15,229 and 8,392 samples collected after primary, first and second booster vaccination, respectively. GMCs at 2-6 and 21-25 weeks after primary series were lower in participants with older age or medical risk conditions. After the first booster, older age was associated with lower GMC at 2-6 weeks and at 21-25 weeks. Waning after the first and second boosters (only 60-85) was not associated with age or medical risk conditions.
Conclusions: Since antibody differences by age and medical risk groups have become small with increasing number of doses, other factors such as COVID-19 disease severity rather than antibody levels are useful for prioritization of additional vaccinations.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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