Platelet-rich fibrin as an adjunct to scaling and root planing in treatment of shallow periodontal pockets: A randomized clinical trial.

Autor: Al-Rihaymee S; Department of Periodontics, College of Dentistry, University of Babylon, Iraq. Electronic address: sarra.anwar1205a@codental.uobaghdad.edu.iq., Mahmood MS; Department of Periodontics, College of Dentistry, University of Baghdad, Iraq., Abdulbaqi HR; Department of Periodontics, College of Dentistry, University of Baghdad, Iraq., Majeed ZN; Department of Periodontics, College of Dentistry, University of Babylon, Iraq.
Jazyk: angličtina
Zdroj: Journal of oral biosciences [J Oral Biosci] 2024 Sep; Vol. 66 (3), pp. 612-618. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1016/j.job.2024.07.002
Abstrakt: Objectives: To evaluate the efficacy of platelet-rich fibrin (PRF) as an adjunct to scaling and root planing (ScRp) for healing shallow periodontal pockets.
Methods: Twelve patients with periodontitis were enrolled in this split-mouth, randomized clinical trial. A total of 24 shallow periodontal pockets (4-6 mm) were treated by either ScRp alone (control) or PRF (test). Clinical attachment loss (CAL), probing pocket depth (PPD), bleeding on probing (BOP), and plaque index (PLI), as well as platelet-derived growth factor-BB (PDGF-BB) by enzyme-linked immunosorbent assay (ELISA) in gingival crevicular fluid (GCF) were measured at baseline and at 1- and 3-month follow-up visits.
Results: At 1- and 3-month follow-up visits, greater CAL gains (2.6 ± 0.25 mm and 3.26 ± 0.31 mm, respectively) and PPD reductions (2.58 ± 0.38 and 3.31 ± 0.39 mm, respectively) were observed in the test group compared to those in controls (CAL gain of 1.01 ± 0.49 mm and 1.43 ± 0.48 mm; PPD reduction of 1.1 ± 0.55 and 1.37 ± 0.49 mm, respectively). In addition, the increase in PDGF-BB in GCF in the test group (724.5 ± 186.09 pg/μl and 1957.5 ± 472.9 pg/μl) was significantly greater than that in controls (109.3 ± 24.07 and 614.64 ± 209.3 pg/μl) at 1- and 3-month follow-up visits, respectively.
Conclusions: The noninvasive use of PRF as an adjunct to ScRp successfully improved clinical periodontal parameters and might contribute to increased PDGF-BB in GCF.
Competing Interests: Declaration of competing interest All the authors certify that they have no conflict of interest to disclose in relation to the subject matter or materials discussed in the present study.
(Copyright © 2024 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: