Modeling the CD8＋ T cell immune response to influenza infection in adult and aged mice.

Autor: Whipple B; Department of Mathematics and Statistical Science, University of Idaho, Moscow, ID, 83844, United States; Bioinformatics and Computational Biology Program, University of Idaho, Moscow, ID, 83844, United States., Miura TA; Bioinformatics and Computational Biology Program, University of Idaho, Moscow, ID, 83844, United States; Department of Biological Sciences, University of Idaho, Moscow, ID, 83844, United States; Institute for Modeling Collaboration and Innovation, University of Idaho, Moscow, ID, 83844, United States., Hernandez-Vargas EA; Department of Mathematics and Statistical Science, University of Idaho, Moscow, ID, 83844, United States; Bioinformatics and Computational Biology Program, University of Idaho, Moscow, ID, 83844, United States; Institute for Modeling Collaboration and Innovation, University of Idaho, Moscow, ID, 83844, United States. Electronic address: esteban@systemsmedicine.de.
Jazyk: angličtina
Zdroj: Journal of theoretical biology [J Theor Biol] 2024 Oct 07; Vol. 593, pp. 111898. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1016/j.jtbi.2024.111898
Abstrakt: The CD8＋ T cell response is the main determinant of viral clearance during influenza infection. However, influenza viral dynamics and the respective immune responses are affected by the host's age. To investigate age-related differences in the CD8＋ T cell immune response dynamics, we propose 16 ordinary differential equation models of existing experimental data. These data consist of viral titer and CD8＋ T cell counts collected periodically over a period of 19 days from adult and aged mice infected with influenza A/Puerto Rico/8/34 (H1N1). We use the corrected Akaike Information Criterion to identify the models which best represent the considered data. Our model selection process indicates differences in mechanisms which reduce the CD8＋ T cell response: linear downregulation is favored for adult mice, while baseline exponential decay is favored for aged mice. Parameter fitting of the top ranked models suggests that the aged population has reduced CD8＋ T cell proliferation compared to the adult population. More experimental work is needed to determine the specific immunological features through which age might cause these differences. A better understanding of the immunological mechanisms by which aging leads to discrepant CD8＋ T cell dynamics may inform future treatment strategies.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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