Incidence and clinical significance of non-tuberculous mycobacteria among migrants in Denmark: A nationwide register-based cohort study from 1991 through 2021.

Autor: Dahl VN; International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Center for Global Health, Aarhus University (GloHAU), Aarhus, Denmark. Electronic address: victor.dahl@rm.dk., Hermansen TS; International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark., Andersen AB; Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., van Ingen J; Radboud University Medical Center, Department of Medical Microbiology, Nijmegen, the Netherlands., Svensson E; International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark., Wejse CM; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Center for Global Health, Aarhus University (GloHAU), Aarhus, Denmark., Lillebaek T; International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Travel medicine and infectious disease [Travel Med Infect Dis] 2024 Sep-Oct; Vol. 61, pp. 102736. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1016/j.tmaid.2024.102736
Abstrakt: Background: There is limited knowledge about non-tuberculous mycobacteria (NTM) infections in migrants. We aimed to assess the incidence and clinical significance of NTM among migrants in Denmark.
Method: Nationwide register-based cohort study of migrants with a positive NTM culture in Denmark from 1991 through 2021, stratified by patient demographics, disease localisation, species, and clinical significance.
Results: 433 migrants had a positive NTM culture, resulting in an overall incidence rate (IR) of 3.7 (95%CI 3.3-4.0) per 100,000 migrants. Overall NTM IRs for definite disease were 1.0 (95%CI 0.9-1.2), possible disease 1.0 (95%CI 0.8-1.2), and isolation 1.7 (95%CI 1.4-1.9) per 100,000 migrants. Migrants had considerably higher age- and sex-adjusted NTM IRs of positive cultures (incidence rate ratio [IRR] = 2.1, 95%CI 1.9-2.3, p < 0.001), possible disease (IRR = 2.4, 95%CI 2.0-3.0, p < 0.001), and isolation (IRR = 4.6, 95%CI 3.9-5.4, p < 0.001) compared to Danish-born, but not of definite disease (IRR = 1.1, 95%CI 0.9-1.3, p = 0.562). IRs of migrants with positive NTM cultures did not increase over time (-0.8 %/year, p = 0.133).
Conclusions: Migrants have a higher, but stable, burden of NTM compared with Danish-born. The higher rates likely reflect that more specimens are examined for Mycobacterium tuberculosis. Microbiologically classified definite NTM disease is not substantially more common among migrants.
Competing Interests: Declaration of competing interest VND and ABA participate on the advisory board for Nordicinfu Care Denmark, which distributes ARIKAYCE® (amikacin liposome inhalation suspension) for Insmed. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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