Non-contact detection of pyrethroids widely used in vector control by Anopheles mosquitoes.

Autor: Kambou SS; MIVEGEC, University Montpellier, IRD, CNRS, Montpellier, France.; Institut de Recherche en Sciences de la Santé (IRSS), Centre National de Recherche Scientifique et Technique (CNRST), Bobo-Dioulasso, Burkina Faso., Valente A; MIVEGEC, University Montpellier, IRD, CNRS, Montpellier, France., Agnew P; MIVEGEC, University Montpellier, IRD, CNRS, Montpellier, France., Hien DFS; Institut de Recherche en Sciences de la Santé (IRSS), Centre National de Recherche Scientifique et Technique (CNRST), Bobo-Dioulasso, Burkina Faso., Yerbanga RS; MIVEGEC, University Montpellier, IRD, CNRS, Montpellier, France.; Institut des Sciences et Techniques (InSTech), Bobo-Dioulasso, Burkina Faso., Moiroux N; MIVEGEC, University Montpellier, IRD, CNRS, Montpellier, France., Dabire KR; Institut de Recherche en Sciences de la Santé (IRSS), Centre National de Recherche Scientifique et Technique (CNRST), Bobo-Dioulasso, Burkina Faso., Pennetier C; MIVEGEC, University Montpellier, IRD, CNRS, Montpellier, France., Cohuet A; MIVEGEC, University Montpellier, IRD, CNRS, Montpellier, France., Carrasco D; MIVEGEC, University Montpellier, IRD, CNRS, Montpellier, France.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Jul 12; Vol. 19 (7), pp. e0298512. Date of Electronic Publication: 2024 Jul 12 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0298512
Abstrakt: Pyrethroids are the most widely used insecticides to control vector borne diseases including malaria. Physiological resistance mechanisms to these insecticides have been well described, whereas those for behavioral resistance remain overlooked. Field data suggest the presence of spatial sensory detection by Anopheles mosquitoes of the pyrethroid molecules used in insecticide-based control tools, such as long-lasting insecticide nets or insecticide residual spraying. This opens the way to the emergence of a wide range of behavioral adaptations among malaria vectors. However, the spatial sensory detection of these molecules is controversial and needs to be demonstrated. The goal of this study was to behaviorally characterize the non-contact detection of three of the most common pyrethroids used for malaria vector control: permethrin, deltamethrin an ⍺-cypermethrin. To reach this goal, we recorded the behavior (takeoff response) of Anopheles gambiae pyrethroid-sensitive and resistant laboratory strains, as well as field collected mosquitoes from the Gambiae Complex, when exposed to the headspace of bottles containing different doses of the insecticides at 25 and 35°C, in order to represent a range of laboratory and field temperatures. We found the proportion of laboratory susceptible and resistant female mosquitoes that took off was, in all treatments, dose and the temperature dependent. Sensitive mosquitoes were significantly more prone to take off only in the presence of ⍺-cypermethrin, whereas sensitive and resistant mosquitoes showed similar responses to permethrin and deltamethrin. Field-collected mosquitoes of the Gambiae Complex were also responsive to permethrin, independently of the species identity (An. gambiae, An. coluzzii and An. arabiensis) or their genotypes for the kdr mutation, known to confer resistance to pyrethroids. The observed ability of Anopheles spp. mosquitoes to detect insecticides without contact could favor the evolution of behavioral modifications that may allow them to avoid or reduce the adverse effect of insecticides and thus, the development of behavioral resistance.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Kambou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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