Mayo Normative Studies: Amyloid and Neurodegeneration Negative Normative Data for the Auditory Verbal Learning Test and Sex-Specific Sensitivity to Mild Cognitive Impairment/Dementia.

Autor:	Stricker NH; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Christianson TJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Pudumjee SB; Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA., Polsinelli AJ; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer's Disease Research Center, Indianapolis, IN, USA., Lundt ES; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Frank RD; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Kremers WK; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Machulda MM; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Fields JA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA., Jack CR; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Knopman DS; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Vemuri P; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Mielke MM; Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 100 (3), pp. 879-897.
DOI:	10.3233/JAD-240081
Abstrakt:	Background: Conventional normative samples include individuals with undetected Alzheimer's disease neuropathology, lowering test sensitivity for cognitive impairment. Objective: We developed Mayo Normative Studies (MNS) norms limited to individuals without elevated amyloid or neurodegeneration (A-N-) for Rey's Auditory Verbal Learning Test (AVLT). We compared these MNS A-N- norms in female, male, and total samples to conventional MNS norms with varying levels of demographic adjustments. Methods: The A-N- sample included 1,059 Mayo Clinic Study of Aging cognitively unimpaired (CU) participants living in Olmsted County, MN, who are predominantly non-Hispanic White. Using a regression-based approach correcting for age, sex, and education, we derived fully-adjusted T-score formulas for AVLT variables. We validated these A-N- norms in two independent samples of CU (n = 261) and mild cognitive impairment (MCI)/dementia participants (n = 392) > 55 years of age. Results: Variability associated with age decreased by almost half in the A-N- norm sample relative to the conventional norm sample. Fully-adjusted MNS A-N- norms showed approximately 7- 9% higher sensitivity to MCI/dementia compared to fully-adjusted MNS conventional norms for trials 1- 5 total and sum of trials. Among women, sensitivity to MCI/dementia increased with each normative data refinement. In contrast, age-adjusted conventional MNS norms showed greatest sensitivity to MCI/dementia in men. Conclusions: A-N- norms show some benefits over conventional normative approaches to MCI/dementia sensitivity, especially for women. We recommend using these MNS A-N- norms alongside MNS conventional norms. Future work is needed to determine if normative samples that are not well characterized clinically show greater benefit from biomarker-refined approaches.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu