KKL-35 inhibits growth of Staphylococcus aureus by systematically changing bacterial phenotypes.
Autor: | Xu J; Department of Laboratory Medicine, The PLA 307 Clinical College, 5th Clinical Medical College of Anhui Medical University, Beijing, China.; Department of Laboratory Medicine, 5th Medical Center of Chinese PLA General Hospital, Beijing, China., Wei Z; Department of Laboratory Medicine, 5th Medical Center of Chinese PLA General Hospital, Beijing, China.; Medical School of Chinese PLA, Beijing, China., Fang W; Department of Laboratory Medicine, The PLA 307 Clinical College, 5th Clinical Medical College of Anhui Medical University, Beijing, China.; Department of Laboratory Medicine, 5th Medical Center of Chinese PLA General Hospital, Beijing, China., Wu J; Department of Laboratory Medicine, 5th Medical Center of Chinese PLA General Hospital, Beijing, China.; Medical School of Chinese PLA, Beijing, China., Wang Y; Beijing Institute of Biotechnology, Beijing, China. wang_you_liang@aliyun.com., Chen S; Department of Laboratory Medicine, The PLA 307 Clinical College, 5th Clinical Medical College of Anhui Medical University, Beijing, China. shpchen@hotmail.com.; Department of Laboratory Medicine, 5th Medical Center of Chinese PLA General Hospital, Beijing, China. shpchen@hotmail.com.; Medical School of Chinese PLA, Beijing, China. shpchen@hotmail.com. |
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Jazyk: | angličtina |
Zdroj: | Archives of microbiology [Arch Microbiol] 2024 Jul 12; Vol. 206 (8), pp. 350. Date of Electronic Publication: 2024 Jul 12. |
DOI: | 10.1007/s00203-024-04079-0 |
Abstrakt: | KKL-35 is a new oxadiazole compound with potent broad-spectrum antibacterial activity against a number of gram-positive and gram-negative bacteria. However, its influences on bacterial growth are unclear. This study is to investigate phenotypic changes of Staphylococcus aureus (SA) caused by KKL-35 and evaluate antibacterial activity of combinations of KKL-35 with 7 class of antibiotics available in medical facilities. KKL-35-treated SA showed significantly lower survival under stresses of NaCl and H (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
Databáze: | MEDLINE |
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