Safety of rezafungin as a long-term treatment option in two patients with complicated fungal infections: two cases from Lecco Hospital (Italy).

Autor:	Ponta G; Infectious Diseases Unit, Ospedale A. Manzoni ASST-Lecco, Lecco, Italy.; Infectious Diseases Unit, Università Vita-Salute S. Raffaele, Milano, Italy., Morena V; Infectious Diseases Unit, Ospedale A. Manzoni ASST-Lecco, Lecco, Italy., Strano M; Infectious Diseases Unit, Ospedale A. Manzoni ASST-Lecco, Lecco, Italy.; Infectious Diseases Unit, Università Vita-Salute S. Raffaele, Milano, Italy., Molteni C; Infectious Diseases Unit, Ospedale A. Manzoni ASST-Lecco, Lecco, Italy., Pontiggia S; Infectious Diseases Unit, Ospedale A. Manzoni ASST-Lecco, Lecco, Italy., Cavalli EM; Plastic and Hand Surgery Department, IRCCS San Gerardo, Monza, Italy., Grancini A; Microbiology and Virology Unit Fondazione IRCCS Cà Granda O. Maggiore Policlinico, Milan, Italy., Mauri C; Microbiology and Virology Unit, A. Manzoni ASST-Lecco, Lecco, Italy., Castagna A; Infectious Diseases Unit, Università Vita-Salute S. Raffaele, Milano, Italy., Galanti A; Cardiac Surgery Unit, A. Manzoni ASST-Lecco, Lecco, Italy., Piconi S; Infectious Diseases Unit, Ospedale A. Manzoni ASST-Lecco, Lecco, Italy.
Jazyk:	angličtina
Zdroj:	Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Aug 07; Vol. 68 (8), pp. e0075024. Date of Electronic Publication: 2024 Jul 12.
DOI:	10.1128/aac.00750-24
Abstrakt:	Rezafungin is an echinocandin characterized by a long elimination half-life which allows for weekly administration. It has been recently approved for the treatment of candidemia. Few data are available about the long-term use of rezafungin and its use for deep infections like endocarditis and osteomyelitis. We describe our experience with its prolonged use in two azole-resistant Candida infections: a case of sacral osteomyelitis and a prosthetic valve endocarditis also involving a thoracic endovascular aneurysm repair. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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