Predominance of CD137 + And TNF-α Expressing CD8 + Central Memory T Cells in Mild COVID-19 Recovered Patients Upon SARS-CoV-2 Re-Exposure.

Autor:	Peixoto RF; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil., de Sousa Palmeira PH; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil., Csordas BG; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil., Cavalcante-Silva LHA; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil., de Andrade AG; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil., de Medeiros IA; Department of Pharmaceutical Sciences, Health Science Center, João Pessoa, Brazil., de Lourdes Assunção Araújo de Azevedo F; Department of Pharmaceutical Sciences, Health Science Center, João Pessoa, Brazil., Veras RC; Department of Pharmaceutical Sciences, Health Science Center, João Pessoa, Brazil., Janebro D; Department of Pharmaceutical Sciences, Health Science Center, João Pessoa, Brazil., Do Amaral IPG; Biotechnology Graduation Program, Federal University of Paraiba, João Pessoa, Brazil., Keesen TSL; Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil.
Jazyk:	angličtina
Zdroj:	Immunological investigations [Immunol Invest] 2024 Oct; Vol. 53 (7), pp. 1092-1101. Date of Electronic Publication: 2024 Jul 12.
DOI:	10.1080/08820139.2024.2376003
Abstrakt:	Introduction: Memory CD8 + T cells are essential for long-term immune protection in viral infections, including COVID-19. Methods: This study examined the responses of CD8 + TEM, TEMRA, and TCM subsets from unvaccinated individuals who had recovered from mild and severe COVID-19 by flow cytometry. Results and Discussion: The peptides triggered a higher frequency of CD8 + TCM cells in the recovered mild group. CD8 + TCM and TEM cells showed heterogeneity in CD137 expression between evaluated groups. In addition, a predominance of CD137 expression in naïve CD8 + T cells, TCM, and TEM was observed in the mild recovered group when stimulated with peptides. Furthermore, CD8 + TCM and TEM cell subsets from mild recovered volunteers had higher TNF-α expression. In contrast, the expression partner of IFN-γ, IL-10, and IL-17 indicated an antiviral signature by CD8 + TEMRA cells. These findings underscore the distinct functional capabilities of each memory T cell subset in individuals who have recovered from COVID-19 upon re-exposure to SARS-CoV-2 antigens.
Databáze:	MEDLINE
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