Screening of Antimicrobial, Antibiofilm, and Cytotoxic Activities of Some Medicinal Plants from Balıkesir Province, Türkiye: Potential Effects of Allium paniculatum Flower.
| Autor: | Oyardı Ö; Gazi University Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Ankara, Türkiye., Hacıoğlu M; İstanbul University Faculty of Pharmacy, Department of Pharmaceutical Microbiology, İstanbul, Türkiye., Özdemir E; Altınbaş University Faculty of Pharmacy, Department of Pharmaceutical Botany, İstanbul, Türkiye., Erbay MŞ; İstanbul University Faculty of Pharmacy, Department of Pharmaceutical Botany, İstanbul, Türkiye., Kültür Ş; İstanbul University Faculty of Pharmacy, Department of Pharmaceutical Botany, İstanbul, Türkiye., Bozkurt Güzel Ç; İstanbul University Faculty of Pharmacy, Department of Pharmaceutical Microbiology, İstanbul, Türkiye. |
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| Jazyk: | angličtina |
| Zdroj: | Turkish journal of pharmaceutical sciences [Turk J Pharm Sci] 2024 Jul 12; Vol. 21 (3), pp. 252-258. |
| DOI: | 10.4274/tjps.galenos.2023.88935 |
| Abstrakt: | Objectives: Plant extracts are important natural resources that may have antimicrobial and antibiofilm effects against pathogens. This study was conducted to investigate the in vitro antimicrobial activities of methanol extracts of some medicinal plants ( Achillea nobilis subspecies neilreichii (A. Kern.) Velen., Aetheorhiza bulbosa (L.) Cass, Allium paniculatum L, Asphodelus aestivus Brot., Ballota nigra L., Cistus laurifolius L., Cistus salviifolius L., Dioscorea communis (L.) Caddick and Wilkin, Galium verum L., Hypericum triquetrifolium Turra, Paliurus spina-christi Mill., Primula vulgaris Huds. subspecies rubra (Sm.) Arcang., Ranunculus arvensis L. and Teucrium polium L.) from Balıkesir province in Türkiye. Materials and Methods: Preliminary antimicrobial activity screening was conducted for all extracts. Antibiofilm activity studies were conducted on mature Candida albicans biofilms. Moreover, the cytotoxicities of A. paniculatum flower extract on A549 and Vero cell lines were determined using a colorimetric tetrazolium-based assay. Results: A. paniculatum flower, P. vulgaris root, C. laurifolius, C. salviifolius , and A. nobilis displayed good activity [minimum inhibitory concentrations (MIC): 9.75, 156, 312, 312 and 312 μg/mL, respectively] against C. albicans American Type Culture Collection 10231. Biofilm studies were conducted on these plant extracts. The methanol extract of A. paniculatum flower decreased the number of C. albicans [colony-forming unit (CFU)/mL] in mature biofilm statistically at 32 x MIC and higher concentrations ( p < 0.01). A. paniculatum flower extract had a cytotoxic effect (killing more than 50% of cells) at high concentrations, and its effect on Vero cells was similar to that on A549 cells. Conclusion: This study demonstrated the importance of the methanol extract of A. paniculatum flower as a natural alternative against C. albicans infections, including biofilms. Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors. (Copyright© 2024 The Author. Published by Galenos Publishing House on behalf of Turkish Pharmacists’ Association.) |
| Databáze: | MEDLINE |
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