Decreasing incidence of celiac disease in Southern Sweden.
| Autor: | Lexner J; Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden.; Department of Clinical Sciences, Lund University, Malmö, Sweden., Clarkson S; Digitalisation MT and IT, Medicon Village, Lund, Sweden., Sjöberg K; Department of Gastroenterology and Nutrition, Skåne University Hospital, Malmö, Sweden.; Department of Clinical Sciences, Lund University, Malmö, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | Scandinavian journal of gastroenterology [Scand J Gastroenterol] 2024 Sep; Vol. 59 (9), pp. 1039-1048. Date of Electronic Publication: 2024 Jul 12. |
| DOI: | 10.1080/00365521.2024.2378045 |
| Abstrakt: | Background: The incidence of celiac disease (CD) has increased rapidly in the late 20 th and early 21 st centuries, but there are recent reports of rates levelling off in countries with a high prevalence. The aim of this study was to investigate current trends in CD in southern Sweden. Patients and Methods: Children and adults diagnosed with CD by biopsy or serology in the region of Skåne, southern Sweden, from 2010-2022 were included. The home address was identified through registers to analyze temporal and geographical trends. Results: A total of 3218 CD-patients were identified (52.2% children), the vast majority detected in clinical care but a few children by screening studies. The age-standardized incidence rate was 18.6 cases/10 5 . The incidence decreased at a rate of -0.75 cases/10 5 (95% CI -1.14 to -0.35, p 0.002). The incidence among girls under 18 years almost halved throughout the study period, decreasing by -2.94 cases/10 5 (95% CI -4.59 to -1.29, p 0.002), while there only were small changes among men. The most common age of onset was 3-9 years. CD incidence varied by place of living and was more common in small towns than urban or rural areas. Conclusions: The incidence of CD in southern Sweden is decreasing, primarily in children and women who traditionally have had the highest risk of CD. CD was diagnosed most frequently in children 3-9 years old. There were regional variations in incidence. CD was most common in small towns, pointing to the importance of environmental factors in CD etiology. |
| Databáze: | MEDLINE |
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