Circulating B vitamins metabolites in depressive disorders - connections with the microbiota-gut-brain axis.

Autor: Śliwiński W; Faculty of Medicine, Medical University of Lodz, Lodz 92-216, Poland. Electronic address: wiktor.sliwinski@stud.umed.lodz.pl., Gawlik-Kotelnicka O; Department of Affective and Psychotic Disorders, Medical University of Lodz, Lodz 92-216, Poland. Electronic address: oliwia.gawlik@umed.lodz.pl.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2024 Aug 24; Vol. 472, pp. 115145. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1016/j.bbr.2024.115145
Abstrakt: Purpose: In this review, we aim to summarize recent information about the association of B vitamins with immune-metabolic aspects of depression and their connection with the gut-brain axis.
Views: B vitamins may alter depressive symptoms by many various mechanisms such as reducing oxidative stress, inflammation, gut permeability, controlling epigenetics, modifying the microbiome, and stimulating it to produce many beneficial substances such as short-chain fatty acids or neurotransmitters: norepinephrine, dopamine, serotonin, gamma-aminobutyric acid, and acetylcholine.
Conclusions: Specifically, vitamins B1 (thiamine), B6 (pyridoxine), B9 (folate), and B12 (cyanocobalamin), B2 (riboflavin) have been observed to affect depression. Given probiotic's capability to produce vitamins from the B group, and modify intestinal function, inflammation, or metabolic dysfunction, their supplementation might be a possible treatment method for the immunometabolic form of depression. Thus, the intake of certain probiotic bacterial strains simultaneously with controlling the required daily intake of B vitamins may positively affect the course of depression. Circulating B vitamins metabolite levels, especially B9, B12, and B6 may also be biomarkers of depression. Further investigation is needed to find stronger evidence on this topic.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: