Effects of Physical Activity on Blood Lipids and Hemoglobin A1c in Healthy Pregnant Women: The FitMum Randomized Controlled Trial.

Autor:	Jensen IKB; Department of Gynecology and Obstetrics, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark. Electronic address: ida.karoline.bach.jensen.01@regionh.dk., Roland CB; Department of Gynecology and Obstetrics, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Knudsen SP; Department of Gynecology and Obstetrics, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Jessen AD; Department of Gynecology and Obstetrics, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Alomairah SA; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Mortensen OH; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Friis-Hansen LJ; Department of Clinical Biochemistry, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Bendix JM; Department of Gynecology and Obstetrics, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark; Department of Clinical Research, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark., Molsted S; Department of Clinical Research, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Stallknecht B; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Clausen TD; Department of Gynecology and Obstetrics, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Gynecology, Fertility and Obstetrics, Copenhagen University Hospital, Rigshospitalet, Denmark., Løkkegaard E; Department of Gynecology and Obstetrics, Copenhagen University Hospital - North Zealand, Hilleroed, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists [Endocr Pract] 2024 Oct; Vol. 30 (10), pp. 927-936. Date of Electronic Publication: 2024 Jul 09.
DOI:	10.1016/j.eprac.2024.07.002
Abstrakt:	Objective: Maternal blood lipid and glucose concentrations during pregnancy affect fetal growth and the risk of pregnancy and delivery complications. We aimed to investigate the effects of physical activity (PA) during pregnancy on maternal blood lipid and hemoglobin A1c (HbA1c) concentrations. We hypothesized that higher PA was associated with improved lipid profile and glycemic control. Methods: In a secondary analysis of a randomized controlled trial, we included 216 pregnant women before week 15 + 0 and tested the effects of two different PA interventions throughout pregnancy compared to standard care on maternal blood lipid and HbA1c concentrations. Additionally, we investigated the effect of PA per se measured by an activity tracker. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride, and HbA1c concentrations were measured at week ≤15 + 0, 28+0-6, 34+0-6, and at delivery (week 32 + 1 to 42 + 0). Effects of the interventions and PA per se were tested using linear mixed effects models and linear regression analyses, respectively. Results: No effects of the PA interventions were detected on maternal lipids or HbA1c during pregnancy. In PA per se analyses, more minutes per week of moderate-to-vigorous intensity PA were associated with less increase in TC (-1.3E-04, P = .020) and LDL-C (-8.5E-05, P = .035) as pregnancy progresses. More active kilocalories were associated with less increase in TC (-5.5E-05, P < .001), HDL-C (-9.5E-06, P = .024), and LDL-C (-3.2E-05, P = .005). Conclusion: Whilst there were no effects of offering PA interventions, higher PA was associated with reduced increases in TC, HDL-C, and LDL-C as pregnancy progressed. Competing Interests: Conflict of Interests Statement The authors have no multiplicity of interest to disclose. This work was supported by The Independent Research Fund Denmark [8020-00353B], TrygFonden [128509], Copenhagen Center for Health Technology [061017], Beckett-Fonden [17–2-0883], Aase and Ejnar Danielsens Fond [10–002052] and Familien Hede Nielsens Fond [2017–1142]. Financial support was also provided by the University of Copenhagen and Copenhagen University Hospital – North Zealand, Hilleroed. None of the external funding bodies interfered with the design of the study, and collection, analysis, and interpretation of data, and the eventual reporting of the study. (Copyright © 2024 AACE. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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