Part II: A new perspective for modeling the bone remodeling process: Biology, mechanics, and pathologies.

Autor: Garzón-Alvarado DA; Biotechnology Institute, Universidad Nacional de Colombia, Colombia; GNUM, Universidad Nacional de Colombia, Colombia. Electronic address: dagarzona@unal.edu.co., Duque-Daza CA; GNUM, Universidad Nacional de Colombia, Colombia., Vaca-González JJ; Escuela de Pregrado - Direccion Académica, Universidad Nacional de, Colombia., Boucetta A; Laboratoire CSPBAT, equipe LBPS, CNRS (UMR 7244), Universit e Sorbonne Paris Nord, France., Linero DL; Civil and Agricultural Department, Universidad Nacional de Colombia, Colombia. Electronic address: dllineros@unal.edu.co., de Boer G; School of Mechanical Engineering, University of Leeds, United Kingdom., Das R; School of Engineering, RMIT University, Australia., Ramtani S; Laboratoire CSPBAT, equipe LBPS, CNRS (UMR 7244), Universit e Sorbonne Paris Nord, France. Electronic address: ramtani@univ-paris13.fr.
Jazyk: angličtina
Zdroj: Journal of theoretical biology [J Theor Biol] 2024 Oct 07; Vol. 593, pp. 111894. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1016/j.jtbi.2024.111894
Abstrakt: In this paper, we explore the effects of biological (pathological) and mechanical damage on bone tissue within a benchmark model. Using the Finite Element Methodology, we analyze and numerically test the model's components, capabilities, and performance under physiologically and pathologically relevant conditions. Our findings demonstrate the model's effectiveness in simulating bone remodeling processes and self-repair mechanisms for micro-damage induced by biological internal conditions and mechanical external ones within bone tissue. This article is the second part of a series, where the first part presented the mathematical model and the biological and physical significance of the terms used in a simplified benchmark model. It explored the bone remodeling model's application, implementation, and results under physiological conditions.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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