Effect of boramidic acid modified carbon nanotubes on neurological, morphological and physiological responses of zebrafish (Danio rerio) embryos and larvae.

Autor: Yiğit A; Department of Pharmacy Services, Tuzluca Vocational School, Igdir University, TR-76000 Igdir, Türkiye. Electronic address: aybek.yigit@igdir.edu.tr., Köktürk M; Department of Organic Agriculture Management, Faculty of Applied Sciences, Igdir University, TR-76000 Igdir, Türkiye., Yıldırım S; Department of Pathology, Veterinary Faculty, Ataturk University, Erzurum, Türkiye; Department of Pathology, Veterinary Faculty, Kyrgyzstan-Türkiye Manas University, Bishkek, Kyrgyzstan., Nazli D; Izmir International Biomedicine and Genome Institute (IBG-Izmir), Dokuz Eylul University, 35340 Izmir, Türkiye; Izmir Biomedicine and Genome Center (IBG), Dokuz Eylul University Health Campus, Inciralti-Balcova 35340, Izmir, Türkiye., Kiliçlioğlu M; Department of Pathology, Veterinary Faculty, Ataturk University, Erzurum, Türkiye., Sahin A; Izmir Biomedicine and Genome Center (IBG), Dokuz Eylul University Health Campus, Inciralti-Balcova 35340, Izmir, Türkiye; Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla 35430, Izmir, Türkiye., Atamanalp M; Department of Aquaculture, Faculty of Fisheries, Ataturk University, Erzurum, Türkiye., Ozhan G; Izmir Biomedicine and Genome Center (IBG), Dokuz Eylul University Health Campus, Inciralti-Balcova 35340, Izmir, Türkiye; Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla 35430, Izmir, Türkiye., Menges N; Department of Biomedical Engineering, Faculty of Engineering, Necmettin Erbakan University, 42100 Konya, Türkiye; Science Technology Research and Application Center (BITAM), Necmettin Erbakan University, 42100 Konya, Türkiye. Electronic address: nurettin.menges@erbakan.edu.tr., Alak G; Department of Seafood Processing Technology, Faculty of Fisheries, Ataturk University, Erzurum, Türkiye. Electronic address: galak@atauni.edu.tr.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 Oct 15; Vol. 947, pp. 174614. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1016/j.scitotenv.2024.174614
Abstrakt: This study aimed to determine the potential toxicological effects of carbon nanotubes (CNTs), their modifications with ethylenediamine (ED) and boric acid (BA) on aquatic organisms. Specifically, the research focused on the morphological, physiological, and histopathological-immuno-histochemical responses in zebrafish (Danio rerio) embryos and larvae, via applying different concentrations of CNTs, CNT-ED, and CNT-ED-BA (Control, 5, 10, and 20 mg/L). The results indicated that 20 mg/L CNT nanoparticles were toxic to zebrafish larvae, with mortality rates increasing with CNT and CNT-ED concentrations, reaching 36.7 % at the highest CNT concentration. The highest dose caused considerable degeneration, necrosis, DNA damage, and apoptosis, as evidenced by histopathological and immunohistochemical tests. In contrast, despite their high concentration, CNT-ED-BA nanoparticles exhibited low toxicity. Behavioral studies revealed that CNT and CNT-ED nanoparticles had a more significant impact on sensory-motor functions compared to CNT-ED-BA nanoparticles. These findings suggest that modifying the nanosurface with boric acid, resulting in boramidic acid, can reduce the toxicity induced by CNT and CNT-ED.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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