[Quantification of Ki-67 in PitNET (pituitary neuroendocrine tumors)/adenomas].

Autor: Klein J; Institut für Neuropathologie der Universität Hamburg, UKE, Martinistraße 52, 20246, Hamburg, Deutschland., Saeger K; Institut für Neuropathologie der Universität Hamburg, UKE, Martinistraße 52, 20246, Hamburg, Deutschland.; VMScope GmbH, Berlin, Deutschland., Saeger W; Institut für Neuropathologie der Universität Hamburg, UKE, Martinistraße 52, 20246, Hamburg, Deutschland. w.saeger@uke.de.
Jazyk: němčina
Zdroj: Pathologie (Heidelberg, Germany) [Pathologie (Heidelb)] 2024 Sep; Vol. 45 (5), pp. 339-343. Date of Electronic Publication: 2024 Jul 11.
DOI: 10.1007/s00292-024-01319-4
Abstrakt: This study is the first to compare the determination of the Ki-67 index in pituitary neuroendocrine tumors (PitNET)/pituitary adenomas by pathologists with a computerized method (Cognition MasterSuite from VMScope, Berlin, Germany). PitNET/pituitary adenomas often show a low proliferation index. Observer variability is high, especially when estimating in this low percentage range. A more reliable determination would be possible using the four-eyes principle, but this cannot be realized continuously; thus, digital image analysis is a promising solution. In the study, there was clear agreement between the Ki-67 estimate by two experienced pathologists and the determination with the aid of digital image analysis. The digital image analysis system is excellent for determining the proliferation rate of PitNET/pituitary adenomas and can therefore be used to determine the "third" and "fourth eye".
(© 2024. The Author(s).)
Databáze: MEDLINE
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