Synthetic MRI and MR Fingerprinting-Derived Relaxometry of Antenatal Human Brainstem Myelination: A Postmortem-Based Quantitative Imaging Study.

Autor:	Schmidbauer VU; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Houech IM; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria.; Department of Diagnostic Imaging (I.-V.M.H.), Medical University of Sofia, Sofia, Bulgaria.; Alexander R. Margulis Fellowship 2022 (I.-V.M.H., J.M.)., Malik J; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Watzenboeck ML; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Mittermaier R; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Kienast P; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Haberl C; Department of Obstetrics and Feto-Maternal Medicine (C. Haberl, T.D., J.B., D.B., H.K.), Medical University of Vienna, Vienna, Austria., Pogledic I; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Mitter C; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Dovjak GO; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Krauskopf A; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Prayer F; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Stuempflen M; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Dorittke T; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria.; Department of Obstetrics and Feto-Maternal Medicine (C. Haberl, T.D., J.B., D.B., H.K.), Medical University of Vienna, Vienna, Austria., Gantner NA; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Binder J; Department of Obstetrics and Feto-Maternal Medicine (C. Haberl, T.D., J.B., D.B., H.K.), Medical University of Vienna, Vienna, Austria., Bettelheim D; Department of Obstetrics and Feto-Maternal Medicine (C. Haberl, T.D., J.B., D.B., H.K.), Medical University of Vienna, Vienna, Austria., Kiss H; Department of Obstetrics and Feto-Maternal Medicine (C. Haberl, T.D., J.B., D.B., H.K.), Medical University of Vienna, Vienna, Austria., Haberler C; Division of Neuropathology and Neurochemistry (C. Haberler, E.G.), Department of Neurology, Medical University of Vienna, Vienna, Austria., Gelpi E; Division of Neuropathology and Neurochemistry (C. Haberler, E.G.), Department of Neurology, Medical University of Vienna, Vienna, Austria., Prayer D; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria., Kasprian G; From the Department of Biomedical Imaging and Image-Guided Therapy (V.U.S., I.-V.M.H., J.M., M.L.W., R.M., P.K., I.P., C.M., G.O.D., A.K., F.P., M.S., T.D., N.A.G., D.P., G.K.), Medical University of Vienna, Vienna, Austria.
Jazyk:	angličtina
Zdroj:	AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2024 Sep 09; Vol. 45 (9), pp. 1327-1334. Date of Electronic Publication: 2024 Sep 09.
DOI:	10.3174/ajnr.A8337
Abstrakt:	Background and Purpose: The radiologic evaluation of ongoing myelination is currently limited prenatally. Novel quantitative MR imaging modalities provide relaxometric properties that are linked to myelinogenesis. In this retrospective postmortem imaging study, the capability of Synthetic MR imaging and MR fingerprinting-derived relaxometry for tracking fetal myelin development was investigated. Moreover, the consistency of results for both MR approaches was analyzed. Materials and Methods: In 26 cases, quantitative postmortem fetal brain MR data were available (gestational age range, 15 + 1 to 32 + 1; female/male ratio, 14/12). Relaxometric measurements (T1-/T2-relexation times) were determined in the medulla oblongata and the midbrain using Synthetic MR imaging/MR fingerprinting-specific postprocessing procedures (Synthetic MR imaging and MR Robust Quantitative Tool for MR fingerprinting). The Pearson correlations were applied to detect relationships between T1-relaxation times/T2-relaxation times metrics and gestational age at MR imaging. Intraclass correlation coefficients were calculated to assess the consistency of the results provided by both modalities. Results: Both modalities provided quantitative data that revealed negative correlations with gestational age at MR imaging: Synthetic MR imaging-derived relaxation times (medulla oblongata [ r = -0.459; P  = .021]; midbrain [ r = -0.413; P  = .040]), T2-relaxation times (medulla oblongata [ r = -0.625; P  < .001]; midbrain [ r = -0.571; P  = .003]), and MR fingerprinting-derived T1-relaxation times (medulla oblongata [ r = -0.433; P  = .035]; midbrain [ r = -0.386; P  = .062]), and T2-relaxation times (medulla oblongata [ r =-0.883; P  < .001]; midbrain [ r = -0.890; P  < .001]).The intraclass correlation coefficient analysis for result consistency between both MR approaches ranged between 0.661 (95% CI, 0.351-0.841) (T2-relaxation times: medulla oblongata) and 0.920 (95% CI, 0.82-0.965) (T1-relaxation times: midbrain). Conclusions: There is a good-to-excellent consistency between postmortem Synthetic MR imaging and MR fingerprinting myelin quantifications in fetal brains older than 15 + 1 gestational age. The strong correlations between quantitative myelin metrics and gestational age indicate the potential of quantitative MR imaging to identify delayed or abnormal states of myelination at prenatal stages of cerebral development. (© 2024 by American Journal of Neuroradiology.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu