Interactions between respiratory syncytial virus and Streptococcus pneumoniae in the pathogenesis of childhood respiratory infections: a systematic review.

Autor:	Besteman SB; Department of Pediatrics, Onze Lieve Vrouwe Gasthuis Ziekenhuis, Amsterdam, Netherlands., Bogaert D; Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Utrecht, Netherlands; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Bont L; Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Utrecht, Netherlands., Mejias A; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Ramilo O; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Weinberger DM; Department of Epidemiology of Microbial Diseases and Public Health Modeling Unit, Yale School of Public Health, New Haven, CT, USA., Dagan R; The Shraga Segal Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address: rdagan@bgu.ac.il.
Jazyk:	angličtina
Zdroj:	The Lancet. Respiratory medicine [Lancet Respir Med] 2024 Nov; Vol. 12 (11), pp. 915-932. Date of Electronic Publication: 2024 Jul 08.
DOI:	10.1016/S2213-2600(24)00148-6
Abstrakt:	Lower respiratory tract infections, commonly caused by respiratory syncytial virus (RSV) or Streptococcus pneumoniae (pneumococcus), pose a substantial global health burden, especially in children younger than 5 years of age. A deeper understanding of the relationship between RSV and pneumococcus would aid the development of health-care approaches to disease prevention and management. We completed a systematic review to identify and assess evidence pertaining to the relationship between RSV and pneumococcus in the pathogenesis of childhood respiratory infections. We found mechanistic evidence for direct pathogen-pathogen interactions and for indirect interactions involving host modulation. We found a strong seasonal epidemiological association between these two pathogens, which was recently confirmed by a parallel decrease and a subsequent resurgence of both RSV and pneumococcus-associated disease during the COVID-19 pandemic. Importantly, we found that pneumococcal vaccination was associated with reduced RSV hospitalisations in infants, further supporting the relevance of their interaction in modulating severe disease. Overall evidence supports a broad biological and clinical interaction between pneumococcus and RSV in the pathogenesis of childhood respiratory infections. We hypothesise that the implementation of next-generation pneumococcal and RSV vaccines and monoclonal antibodies targeting RSV will act synergistically to reduce global morbidity and mortality related to childhood respiratory infections. Competing Interests: Declaration of interests LB and RD obtained a research grant from the Investigator-Initiated Studies Program of Merck Sharp & Dohme (MSD) to cover the costs of Violicom's searches and screening of the data. LB is the founding chairman of the Respiratory Syncytial Virus Foundation (ReSViNET Foundation); he has regular interactions with pharmaceutical and other industrial partners, but he has not received personal fees or other personal benefits. LB reports the following funding to his institution: funding for investigator-initiated studies from AbbVie, MedImmune, AstraZeneca, Sanofi, Janssen, Pfizer, MSD, and MeMed Diagnostics; funding for the RSV GOLD study from the Bill & Melinda Gates Foundation; funding as part of the Innovative Medicines Initiative-funded RESCEU and PROMISE projects with partners GSK, Novavax, Janssen, AstraZeneca, Pfizer, and Sanofi; funding for participation in clinical studies sponsored by MedImmune and Pfizer from Julius Clinical; and consulting fees and fees for invited lectures from AbbVie, MedImmune, Ablynx, Bavaria Nordic, MabXience, GSK, Novavax, Pfizer, Moderna, AstraZeneca, MSD, Sanofi, and Janssen. AM has received research grants to her institution from Janssen, Merck, and the US National Institutes of Health (NIH); fees for participation on advisory boards from Janssen, Sanofi Pasteur, Merck, Pfizer, and AstraZeneca; and fees for lectures from Sanofi Pasteur and AstraZeneca. OR has received research grants to his institution from Janssen, Merck, NIH, and the Bill & Melinda Gates Foundation; fees for participation on advisory boards from Sanofi Pasteur, Merck, and Pfizer; and fees for lectures from Pfizer, Sanofi Pasteur, and AstraZeneca. DMW is supported by a grant from the NIH National Institute of Allergy and Infectious Diseases (R01AI137093) and has received consulting fees from Pfizer, Merck, and GSK/Affinivax for work unrelated to this manuscript; he is the principal investigator on grants from Pfizer and Merck to his institution for work unrelated to this manuscript. RD has received grants to his institution from Pfizer, MSD, and MedImmune/AstraZeneca; consulting fees and fees for participation on advisory boards from Pfizer and MSD; payment for speakers bureaus from Pfizer, MSD, Sanofi Pasteur, and GSK; and payment for expert testimony from Pfizer. SBB and DB declare no competing interests. (Copyright © 2024 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies.)
Databáze:	MEDLINE
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