How did plants evolve the prenylation of specialized phenolic metabolites by means of UbiA prenyltransferases?

Autor: Munakata R; Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Uji 611-0011, Japan., Yazaki K; Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Uji 611-0011, Japan. Electronic address: yazaki.kazufumi.6w@kyoto-u.ac.jp.
Jazyk: angličtina
Zdroj: Current opinion in plant biology [Curr Opin Plant Biol] 2024 Oct; Vol. 81, pp. 102601. Date of Electronic Publication: 2024 Jul 11.
DOI: 10.1016/j.pbi.2024.102601
Abstrakt: Prenylated phenolics occur in over 4000 species in the plant kingdom, most of which are known as specialized metabolites with high chemical diversity. Many of them have been identified as pharmacologically active compounds from various medicinal plants, in which prenyl residues play a key role in these activities. Prenyltransferases (PTs) responsible for their biosynthesis have been intensively studied in the last two decades. These enzymes are membrane-bound proteins belonging to the UbiA superfamily that occurs from bacteria to humans, and in particular those involved in plant specialized metabolism show strict specificities for both substrates and products. This article reviews the enzymatic features of plant UbiA PTs, including C- and O-prenylation, molecular evolution, and application of UbiA PTs in synthetic biology.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Artificial intelligence was used to improve readability and language.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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