Amifostine loaded lipid-calcium carbonate nanoparticles as an oral drug delivery system for radiation protection.

Autor: Wang C; School of Pharmacy, Changzhou University, Changzhou, Jiangsu, China., Ji L; School of Pharmacy, Changzhou University, Changzhou, Jiangsu, China., Wang J; School of Pharmacy, Changzhou University, Changzhou, Jiangsu, China., Zhang J; School of Pharmacy, Changzhou University, Changzhou, Jiangsu, China., Qiu L; School of Pharmacy, Changzhou University, Changzhou, Jiangsu, China. Electronic address: linqiu@cczu.edu.cn., Chen S; The Affiliated Changzhou No.2 People's Hospital, Nanjing Medical University, Changzhou, Jiangsu, China; Jiangsu Province Engineering Research Center of Medical Physics, Changzhou, Jiangsu 213003, China. Electronic address: chenshaoqing@zju.edu.cn., Ni X; The Affiliated Changzhou No.2 People's Hospital, Nanjing Medical University, Changzhou, Jiangsu, China; Jiangsu Province Engineering Research Center of Medical Physics, Changzhou, Jiangsu 213003, China. Electronic address: nxy@njmu.edu.cn.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Aug; Vol. 177, pp. 117029. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1016/j.biopha.2024.117029
Abstrakt: Amifostine (AMF) as the first-line radiation protection drug, usually suffered from low compliance and short half-life upon clinical applications. The development of oral drug delivery system (DDS) for AMF is a promising solution. However, the inherent shortages of AMF present significant challenges in the design of suitable oral DDS. Here in this study, we utilized the ability of calcium ions to bind with AMF and prepared AMF loaded calcium carbonate (CC) core, CC/AMF, using phase transferred coprecipitation method. We further modified the CC/AMF using phospholipids to prepare AMF loaded lipid-calcium carbonate (LCC) hybrid nanoparticles (LCC/AMF) via a thin-film dispersion method. LCC/AMF combines the oral advantages of lipid nanoparticles with the drug-loading capabilities of CC, which was shown as uniform nano-sized formulation with decent stability in aqueous solution. With favorable intestinal transport and absorption effects, it effectively enhances the in vivo radiation protection efficacy of AMF through oral administration. More importantly, we further investigated the cellular accumulation profile and intracellular transport mechanism of LCC/AMF using MDCK and Caco-2 cell lines as models. This research not only alters the current administration method of AMF to enhance its convenience and compliance, but also provides insights and guidance for the development of more suitable oral DDS for AMF in the future.
Competing Interests: Declaration of Competing Interest The authors declare no competing financial interest.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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