A preliminary investigation of the acute effects of delta-9-tetrahydrocannabinol on pain and opioid attentional bias among persons with opioid use disorder.

Autor: Wolkowicz NR; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven, CT, USA. Electronic address: Noah.Wolkowicz@va.gov., Sofuoglu M; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven, CT, USA., Pittman B; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA., Meyerovich J; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven, CT, USA., MacLean RR; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven, CT, USA., De Aquino JP; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven, CT, USA; Clinical Neuroscience Research Unit, Connecticut Mental Health Center, New Haven, CT, USA. Electronic address: joao.deaquino@yale.edu.
Jazyk: angličtina
Zdroj: Journal of psychiatric research [J Psychiatr Res] 2024 Sep; Vol. 177, pp. 90-95. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1016/j.jpsychires.2024.06.047
Abstrakt: Introduction: Attentional bias (AB) is believed to be an important factor in the development and maintenance of both opioid use disorder (OUD) and chronic pain. Cannabis and its main psychoactive constituent, delta-9-tetrahydrocannabinol (THC), produce analgesic effects via processes that are potentially relevant to AB and is commonly used by persons with OUD. This exploratory study investigated if THC influences AB towards pain and opioid cues individuals with OUD.
Methods: Using a within-subject, crossover design, 27 adults receiving methadone were randomly assigned to receive single doses of oral THC (10 mg, 20 mg administered as dronabinol) or placebo across three, 5-h sessions. During each session, a visual probe task was used to measure AB to pain and opioid cues at baseline and 120 min post-THC administration.
Results: Mixed-effects models examined main effects of THC dose, time, and their interaction across all participants; findings were then stratified by methadone dose (low dose <90 mg/day and high dose ≥90 mg/day). Among individuals receiving high doses of methadone, a significant interaction was observed such that AB towards opioids increased following 10 mg THC administration and decreased following 20 mg THC administration. Additionally, participants receiving low doses of methadone showed significant increases in the variability of opioid-related AB post THC administration.
Conclusion: We provide preliminary evidence showing that THC may cause dose-dependent effects on selective attention for opioid cues among methadone patients. These results underscore the need for further clinical investigation into the effects of cannabinoids and other substances with potential analgesic and addictive properties among persons with OUD.
Competing Interests: Declaration of competing interest None. Funding Statement This work was supported by the Robert E. Leet and Clara Guthrie Patterson Mentored Clinical Research Award and by the VISN-1 Mental Illness Research, Education, and Clinical Center (MIRECC) Pilot Award Program. Joao P. De Aquino is supported by Grants K23DA052682 and R21DA057240 from the National Institute on Drug Abuse (NIDA). R. Ross MacLean is supported by a Development Career Development Award 1IK2CX002286 from VA Clinical Science Research and Development (CSR&D). Other than providing funding, the Patterson Trust, the VA and NIDA had no role in the conception and conduction of this project or in the interpretation or reporting of its findings.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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