Reevaluating Diagnosis of Sarcoidosis: Biopsy with Necrosis in Mycobacterial Endemic Areas.

Autor:	Manwatkar AA; Assistant Professor, Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India., Das JK; Senior Resident, Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India., Issac NPR; Assistant Professor, Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India., Kothapalli N; Senior Resident, Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India., Chandhu AS; Assistant Professor, Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India., Prabhu V; Assistant Professor, Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India., Mathew J; Professor, Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India, Corresponding Author.
Jazyk:	angličtina
Zdroj:	The Journal of the Association of Physicians of India [J Assoc Physicians India] 2024 Jul; Vol. 72 (7), pp. 94-96.
DOI:	10.59556/japi.72.0509
Abstrakt:	Background: Sarcoidosis is a multisystem inflammatory disease with a variable presentation. The most characteristic feature of sarcoidosis is nonnecrotizing granulomas. However, when sarcoidosis presents with rare organ involvement, and biopsy shows necrosis, the diagnosis becomes challenging. Case Presentation: Here, we present three cases of sarcoidosis with unusual organ involvement and biopsy findings of necrosis, leading to a delay in diagnosis and treatment. Case 1 was presented with lymphoreticular involvement within the intraparotid lymph node and genitourinary area. Biopsy from the epididymis showed necrosis, initially leading to treatment for tuberculosis (TB). Case 2 describes lymphoreticular involvement and cardiac symptoms. His cervical and bone marrow biopsies showed necrosis. Case 3's presentation was disseminated lymphadenopathy with hepatosplenomegaly, initially suspected as malignancy or TB. Conclusion: While biopsy plays a significant role in diagnosing sarcoidosis, the presence of necrosis alone should not lead to its exclusion. (© Journal of the Association of Physicians of India 2024.)
Databáze:	MEDLINE
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