Dose-response relationship between arsenic in drinking water and mortality of urinary cancers in Taiwan.

Autor: Chung YL; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan, 70428, Taiwan., Lin MH; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan, 70428, Taiwan.; Division of Hematology and Oncology, Department of Internal Medicine, An Nan Hospital, China Medical University, Tainan, Taiwan., Liaw YP; Department of Public Health, Chung Shan Medical University, Taichung, Taiwan., Guo HR; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan, 70428, Taiwan. hrguo@mail.ncku.edu.tw.; Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan, Taiwan. hrguo@mail.ncku.edu.tw.; Department of Occupational and Environmental Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. hrguo@mail.ncku.edu.tw.
Jazyk: angličtina
Zdroj: Environmental geochemistry and health [Environ Geochem Health] 2024 Jul 11; Vol. 46 (8), pp. 299. Date of Electronic Publication: 2024 Jul 11.
DOI: 10.1007/s10653-024-02069-1
Abstrakt: Ingested arsenic is carcinogenic to the human urinary tract, but uncertainties remain regarding the dose-response relationship. To assess dose-response relationships between arsenic ingestion and urinary cancers, we evaluated the associations between the arsenic level in drinking water and mortality of cancers of the bladder, kidney, and prostate in Taiwan. We utilized the 1971-2000 Taiwan death registry data and calculated the age-standardized mortality rates (ASMRs) using the 1976 world standard population as the reference group. We used the data from a 1974-1976 census survey of wells on the arsenic levels in drinking water conducted by the government to assess exposure levels, which had been divided into three categories: below 0.05 ppm, 0.05-0.35 ppm, and above 0.35 ppm. The data were analyzed using multiple linear regression models and geographical information system. We found no increase in ASMR for all, or any, of the urinary cancers at exposure levels of 0.05-0.35 ppm arsenic, but at exposure levels > 0.35 ppm arsenic was associated with increased ASMR in both males and females for bladder cancer, kidney cancer, and all urinary cancers combined. There was no increased ASMR associated with prostate cancer observed for either exposure category.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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