Impact of Toll-like receptor 2 (rs5743708) gene polymorphism in pediatric pneumonia: risk and severity.

Autor:	Abd El-Hamid SM; Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Abd Elalim AA; Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Mansour ENA; Department of Pediatrics, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Moustafa S; Department of Pediatrics, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Moazen EM; Department of Chest disease, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Abdo WH; Department of Radio-diagnosis, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Abou Elnour AKA; Department of Radio-diagnosis, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Elsheikh AA; Department of Community and Occupational Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	The Egyptian journal of immunology [Egypt J Immunol] 2024 Jul; Vol. 31 (3), pp. 48-55.
Abstrakt:	Pediatric pneumonia is a common respiratory infection that affects children and is thought to be a major source of mortality and morbidity worldwide, particularly in low- and middle-income nations. Toll-like receptor2 (TLR2) is an important receptor involved in the recognition of bacterial pathogens and the activation of the immune response. Genetic variability in TLR2 may partially explain individual differences in susceptibility to infections. The purpose of this study was to investigate the possible contribution of the TLR2 (rs5743708) variant to the risk and severity of pediatric pneumonia infection. The study included 100 pediatric patients diagnosed with pneumonia and 100 normal controls who were age and gender matched. Real-time polymerase chain reaction (PCR) was used to genotype participants for the TLR2 (rs5743708) variant. The analysis revealed that children with the TLR2 (rs5743708) (G/A) genotype showed a 2.52-fold greater risk of having pneumonia (OR: 2.52; 95% CI: 1.32-4.79; p = 0.005) in comparison with patients who have wild homozygous genotypes. Furthermore, we observed that the TLR2 (rs5743708) (A) allele is connected to a greater risk of pneumonia infection in children (OR: 1.612; 95% CI: 1.07-2.43; p = 0.023) but did not significantly influence infection severity. In conclusion, children with the TLR2 (rs5743708) mutant (G/A) genotype and (A) allele had a significantly higher risk of having pneumonia, but they were not at high risk for the severity of the infection. (Copyright© by the Egyptian Association of Immunologists.)
Databáze:	MEDLINE
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