Unveiling the potential of photodynamic therapy with nanocarriers as a compelling therapeutic approach for skin cancer treatment: current explorations and insights.

Autor:	Mohanty S; Industrial Research Laboratory, Department of Pharmacy, FD-III, Birla Institute of Technology and Science, Pilani (BITS-PILANI) Pilani Campus, Vidya Vihar Pilani Rajasthan 333031 India gautam.singhvi@pilani.bits-pilani.ac.in h20210307P@alumni.bits-pilani.ac.in h20210302@pilani.bits-pilani.ac.in p20180038@pilani.bits-pilani.ac.in., Desai VM; Industrial Research Laboratory, Department of Pharmacy, FD-III, Birla Institute of Technology and Science, Pilani (BITS-PILANI) Pilani Campus, Vidya Vihar Pilani Rajasthan 333031 India gautam.singhvi@pilani.bits-pilani.ac.in h20210307P@alumni.bits-pilani.ac.in h20210302@pilani.bits-pilani.ac.in p20180038@pilani.bits-pilani.ac.in., Jain R; Industrial Research Laboratory, Department of Pharmacy, FD-III, Birla Institute of Technology and Science, Pilani (BITS-PILANI) Pilani Campus, Vidya Vihar Pilani Rajasthan 333031 India gautam.singhvi@pilani.bits-pilani.ac.in h20210307P@alumni.bits-pilani.ac.in h20210302@pilani.bits-pilani.ac.in p20180038@pilani.bits-pilani.ac.in., Agrawal M; School of Pharmacy & Technology Management, NMIMS Hyderabad India muktaagrawal2410@gmail.com., Dubey SK; Medical Research R&D Healthcare Division, Emami Ltd Kolkata India sunilbit2014@gmail.com., Singhvi G; Industrial Research Laboratory, Department of Pharmacy, FD-III, Birla Institute of Technology and Science, Pilani (BITS-PILANI) Pilani Campus, Vidya Vihar Pilani Rajasthan 333031 India gautam.singhvi@pilani.bits-pilani.ac.in h20210307P@alumni.bits-pilani.ac.in h20210302@pilani.bits-pilani.ac.in p20180038@pilani.bits-pilani.ac.in.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2024 Jul 10; Vol. 14 (30), pp. 21915-21937. Date of Electronic Publication: 2024 Jul 10 (Print Publication: 2024).
DOI:	10.1039/d4ra02564d
Abstrakt:	Skin carcinoma is one of the most prevalent types of carcinomas. Due to high incidence of side effects in conventional therapies (radiotherapy and chemotherapy), photodynamic therapy (PDT) has gained huge attention as an alternate treatment strategy. PDT involves the administration of photosensitizers (PS) to carcinoma cells which produce reactive oxygen species (ROS) on irradiation by specific wavelengths of light that result in cancer cells' death via apoptosis, autophagy, or necrosis. Topical delivery of PS to the skin cancer cells at the required concentration is a challenge due to the compounds' innate physicochemical characteristics. Nanocarriers have been observed to improve skin permeability and enhance the therapeutic efficiency of PDT. Polymeric nanoparticles (NPs), metallic NPs, and lipid nanocarriers have been reported to carry PS successfully with minimal side effects and high effectiveness in both melanoma and non-melanoma skin cancers. Advanced carriers such as quantum dots, microneedles, and cubosomes have also been addressed with reported studies to show their scope of use in PDT-assisted skin cancer treatment. In this review, nanocarrier-aided PDT in skin cancer therapies has been discussed with clinical trials and patents. Additionally, novel nanocarriers that are being investigated in PDT are also covered with their future prospects in skin carcinoma treatment. Competing Interests: The authors declare no competing interests. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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