Anisodamine for the prevention of contrast-induced nephropathy in patients with acute coronary syndrome: a pilot systematic review and meta-analysis of randomized controlled trials.

Autor:	Jain H; Department of Internal Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur., Odat RM; Faculty of Medicine, Jordan University of Science and Technology, Irbid., Jain J; Department of Internal Medicine, All India Institute of Medical Sciences (AIIMS), Jodhpur., Dey D; Medical College Kolkata, Kolkata, West Bengal., Hussein AM; Faculty of Medicine, Al-Balqa' Applied University, Salt, Jordan., Marsool MDM; Department of Internal Medicine, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq., Shahbaz H; Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan., Mathur A; Department of Internal Medicine, Jhalawar Hospital and Medical College, Jhalawar, Rajasthan, India., Yadav H; Department of Internal Medicine, Jhalawar Hospital and Medical College, Jhalawar, Rajasthan, India., Passey S; Department of Internal Medicine, University of Connecticut Health Center, CT, USA., Yadav R; Department of Internal Medicine, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2024 May 21; Vol. 86 (7), pp. 4123-4129. Date of Electronic Publication: 2024 May 21 (Print Publication: 2024).
DOI:	10.1097/MS9.0000000000002181
Abstrakt:	Introduction: Contrast-induced nephropathy (CIN) is a common post-procedural complication of percutaneous coronary intervention for acute myocardial infarction (AMI). Anisodamine hydrobromide is an alkaloid that has demonstrated efficacy in improving microcirculation. This meta-analysis aims to evaluate the reno-protective effects of Anisodamine in patients undergoing percutaneous coronary intervention (PCI) for AMI. Methods: PubMed, Embase, Cochrane Library, Scopus, and clinicaltrials.gov were searched from inception to January 2024 for randomized controlled trials (RCTs) comparing the efficacy of Anisodamine in preventing the development of CIN. Outcomes of interest included the incidence of CIN, serum creatinine levels, and estimated glomerular filtration rate (eGFR). A random-effects model was used for pooling standard mean differences (SMDs) and odds ratios (ORs) with a 95% CI. Statistical significance was considered at a P less than 0.05. Results: Three RCTs involving 563 patients were included. Anisodamine was associated with a reduction in the incidence of CIN [OR: 0.44; 95% CI: 0.28, 0.69; P =0.0003], a reduction in serum creatinine levels at 48 [SMD: -6.78; 95% CI: -10.54,-3.02; P =0.0004] and 72 h [SMD: -6.74; 95% CI: -13.33,-0.15; P =0.03], and a higher eGFR at 24 [SMD: 5.77; 95% CI: 0.39, 11.14; P =0.03], and 48 h [SMD: 4.70; 95% CI: 2.03,7.38; P =0.0006]. The levels of serum creatinine at 24 h and eGFR value at 72 h were comparable between both groups. Conclusions: Anisodamine has demonstrated clinical efficacy in ameliorating the development of CIN post-PCI in AMI patients. Large, multi-centric RCTs are warranted to evaluate the robustness of these findings. Competing Interests: The authors declare no conflicts of interest.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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