Case report: The diagnostic pitfall of Warthin-like mucoepidermoid carcinoma.

Autor:	Yang Y; Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, China., Lei Z; Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, China., Lang Y; Department of Pathology, The Chinese Medicine Hospital of Zhaotong, Zhaotong, China., Wu L; Department of Radiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China., Hu J; Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, China., Liu S; Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, China., Hu Z; Department of Pathology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China., Pan G; Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2024 Jun 20; Vol. 14, pp. 1391616. Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024).
DOI:	10.3389/fonc.2024.1391616
Abstrakt:	Warthin-like mucoepidermoid carcinoma (WL-MEC) is a newly reported variant of mucoepidermoid carcinoma. Its histological feature is easy to confused with metaplastic Warthin Tumor, and its relationship with Warthin tumor in histogenesis is controversial. In this study, we presented two cases of WL-MEC, discussing their clinicopathological and molecular features. Notably, one case was initially misdiagnosed during the first onset of the tumor. Case 1 was a 60-year-old female with a mass in the right parotid gland. Case 2 featured a 29-year-old male who developed a lump at the original surgical site 6 months after a "Warthin tumor" resection from the submandibular gland. Histologically, both tumor exhibited a prominent lymphoid stroma and cystic pattern, accompanied by various amounts of epithelial nests composed of squamoid cells, intermediate cells and mucinous cells. The characteristic eosinophilic bilayer epithelium of Warthin tumor was not typically presented in either case. Both cases tested positive for MAML2 gene rearrangement. To contextualize our findings, we conducted a comprehensive review of forty-eight WL-MEC cases documented in the English literature, aiming to synthesizing a reliable differential diagnostic approach. WL-MEC is a rare yet clinically relevant variant, posing a diagnostic pitfall for pathologists. Our study underscores the importance of a meticulous evaluation of both clinical and histological features, coupled with the detection of MAML2 rearrangement, as a credible method for distinguishing WL-MEC from other benign and malignant lesions, particularly metaplastic Warthin tumor. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Yang, Lei, Lang, Wu, Hu, Liu, Hu and Pan.)
Databáze:	MEDLINE
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