Maternal immune activation affects female offspring whisker movements during object exploration in a rat model of neurodevelopmental disorders.

Autor:	Simanaviciute U; Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, M1 5GD, UK., Potter HG; Institute for Behaviour, Sport and Rehabilitation, School of Medicine & Dentistry, University of Central Lancashire, Burnley, BB11 1RA, UK.; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK., Hager R; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK., Glazier J; Division of Evolution, Infection and Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK., Hodson-Tole E; Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, M1 5GD, UK., Gigg J; Division of Neuroscience, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., Grant R; Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, M1 5GD, UK.
Jazyk:	angličtina
Zdroj:	Brain, behavior, & immunity - health [Brain Behav Immun Health] 2024 Jun 12; Vol. 39, pp. 100807. Date of Electronic Publication: 2024 Jun 12 (Print Publication: 2024).
DOI:	10.1016/j.bbih.2024.100807
Abstrakt:	Poly I:C rat offspring are used to investigate the effects of in utero exposure to maternal immune activation (MIA) and have been suggested as a model of neurodevelopmental disorders (NDD). The behavioural symptoms of this model are diverse and can vary with external factors, including the choice of background strain and husbandry practices. Measuring whisker movements provides quantitative, robust measurements of sensory, motor and cognitive behaviours in rodents. In this study, whisker movements were investigated in 50-day-old male and female offspring of MIA-exposed rat dams and compared to age-matched offspring of control (vehicle) dams. Rat offspring were filmed using high-speed videography in a sequential object exploration task with smooth and textured objects. Poly I:C treatment effects were found in female offspring that did not increase whisker mean angular position during object exploration, especially for the smooth object, indicating an attentional deficit. Whisker tracking during object exploration is demonstrated here, for the first time, as a useful, quick and non-invasive tool to identify both treatment effects and sex differences in a model of MIA-induced NDDs. Competing Interests: We declare no conflicts of interest. (© 2024 The Authors.)
Databáze:	MEDLINE
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