Doxycycline pharmacokinetics and tissue depletion in striped catfish (Pagasianodon hypophthalmus) after oral administration.

Autor: Vinh PQ; College of Aquaculture and Fisheries, Can Tho University, Can Tho, Vietnam., Thinh NQ; College of Aquaculture and Fisheries, Can Tho University, Can Tho, Vietnam., Devreese M; Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Croubels S; Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium., Oanh DTH; College of Aquaculture and Fisheries, Can Tho University, Can Tho, Vietnam., Dalsgaard A; Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark., Maita M; Laboratory of Fish Health Management, Tokyo University of Marine Science and Technology, Minato, Tokyo, Japan., Phu TM; College of Aquaculture and Fisheries, Can Tho University, Can Tho, Vietnam.
Jazyk: angličtina
Zdroj: Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2024 Jul 10. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1111/jvp.13471
Abstrakt: The pharmacokinetics and residue depletion of doxycycline (DOX) in striped catfish (Pagasianodon hypophthalmus) after oral dosage were investigated. The pharmacokinetic experiment was conducted in an aquarium, while the experiment of residue depletion was performed in both an aquarium and earth ponds. Medicated feed was administered orally using the gavage method at a dosage of 20 mg/kg body weight. Blood, liver, and kidney from medicated fish samples were collected. In the depletion experiments, fish were fed medicated feed for five consecutive days at a dosage of 20 mg/kg body weight, with samples collected during and after medication. The concentrations of DOX were quantified using an LC-MS/MS system. The pharmacokinetics parameters of DOX in striped catfish included the absorption rate constant (k a ), absorption half-life (T 1/2abs ), maximal plasma concentration (C max ), time to maximal plasma concentration (T max ), and area under the plasma concentration-time curve from time 0 to 96 h (AUC 0-96 h ) which were 0.12 h -1 , 5.68 h, 1123.45 ng/mL, 8.19 h, and 25,018 ng/mL/h, respectively. Residue depletion results indicated that the withdrawal times of DOX in muscle (with skin) from fish kept in the aquarium were slightly longer than that in fish raised in earth ponds, corresponding to 194 degree-days compared with 150 degree-days. In conclusion, administration of DOX at the dosage of 20 mg/kg body weight can be used for treatment of bacterial infections in striped catfish, and a withdrawal time of 5 days at 29.4°C will ensure consumer food safety due to the rapid depletion of DOX from muscle and skin.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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