Factors associated with neonatal sepsis among neonates admitted in Kibungo Referral Hospital, Rwanda.

Autor: Niyoyita JC; Rwanda Field Epidemiology and Laboratory Training Program, Department of Biostatistics and Epidemiology, School of Public Health, University of Rwanda, P.O. Box 3286, Kigali, Rwanda. niyoy2020@gmail.com.; African Research and Community Health Initiative, Kigali, Rwanda. niyoy2020@gmail.com., Ndayisenga J; African Research and Community Health Initiative, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Omolo J; Rwanda Field Epidemiology and Laboratory Training Program, Department of Biostatistics and Epidemiology, School of Public Health, University of Rwanda, P.O. Box 3286, Kigali, Rwanda., Niyompano H; Rwanda Field Epidemiology and Laboratory Training Program, Department of Biostatistics and Epidemiology, School of Public Health, University of Rwanda, P.O. Box 3286, Kigali, Rwanda.; Rwanda Biomedical Centre, Kigali, Rwanda., Bimenyimana PC; Rwanda Field Epidemiology and Laboratory Training Program, Department of Biostatistics and Epidemiology, School of Public Health, University of Rwanda, P.O. Box 3286, Kigali, Rwanda., Dzinamarira T; University of Pretoria, Pretoria, South Africa., Nsekuye O; Rwanda Biomedical Centre, Kigali, Rwanda., Chavez I; University of California, Los Angeles (UCLA), Los Angeles, USA., Hakizayezu F; Rwanda Field Epidemiology and Laboratory Training Program, Department of Biostatistics and Epidemiology, School of Public Health, University of Rwanda, P.O. Box 3286, Kigali, Rwanda.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jul 10; Vol. 14 (1), pp. 15961. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1038/s41598-024-66818-z
Abstrakt: More than one million neonatal deaths occur every year worldwide, of which 99% take place in low-income countries. In Rwanda, nearly 71% of neonatal deaths are preventable and among these, 10% are due to neonatal sepsis. Nevertheless, limited information exists on neonatal sepsis and its associated factors in Rwanda. The objectives of the study were to find prevalence and factors associated with neonatal sepsis among neonates admitted in Kibungo Referral Hospital, Ngoma District, Rwanda. We used a retrospective cross-sectional study design reviewing a subset of neonatal, maternal and laboratory records from Kibungo Hospital in 2017. Data were reviewed and collected from March to May, 2018. Logistic regression and odds ratios were calculated to identify the factors associated with neonatal sepsis at 95% CI, p < 0.05. Of the 972 total neonates' medical records from 2017, we randomly selected 422 of which 12.8% (n = 54) had neonatal sepsis. When blood cultures were positive, 62% grew Klebsiella pneumoniae. Among neonates with sepsis, 38 (70%) recovered while 16 (30%) died. Neonatal sepsis was strongly associated with neonatal age less than or equal to three days (aOR: 2.769, 95% CI 1.312-5.843; p = 0.008); and gestational age less than 37 weeks (aOR: 4.149; CI 1.1878-9.167; p ≤ 0.001). Increased use of blood cultures including sensitivity testing, routine surface cultures of the neonatology and maternity wards facilities, and systematic ward cleaning are all important approaches to prevent and treat neonatal infections in additional to regular neonatal sepsis evaluations.
(© 2024. The Author(s).)
Databáze: MEDLINE
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