Developmental trajectories of EEG aperiodic and periodic components in children 2-44 months of age.

Autor: Wilkinson CL; Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA. carol.wilkinson@childrens.harvard.edu.; Harvard Medical School, Boston, MA, USA. carol.wilkinson@childrens.harvard.edu., Yankowitz LD; Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chao JY; Department of Anesthesiology, Montefiore Medical Center, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA., Gutiérrez R; Departamento de Anestesia y Medicina Perioperatoria, Hospital Clínico de la Universidad de Chile, Santiago, Chile.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA., Rhoades JL; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; Program in Neuroscience, Division of Medical Sciences, Graduate School of Arts and Sciences, Harvard University, Cambridge, MA, USA., Shinnar S; The Saul R. Korey Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Purdon PL; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA., Nelson CA; Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Harvard Graduate School of Education, Cambridge, MA, USA.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Jul 10; Vol. 15 (1), pp. 5788. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1038/s41467-024-50204-4
Abstrakt: The development of neural circuits has long-lasting effects on brain function, yet our understanding of early circuit development in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected from 592 healthy 2-44 month-old infants, revealing age-dependent nonlinear changes suggestive of distinct milestones in early brain maturation. Developmental changes in periodic peaks include (1) the presence and then absence of a 9-10 Hz alpha peak between 2-6 months, (2) nonlinear changes in high beta peaks (20-30 Hz) between 4-18 months, and (3) the emergence of a low beta peak (12-20 Hz) in some infants after six months of age. We hypothesized that the emergence of the low beta peak may reflect maturation of thalamocortical network development. Infant anesthesia studies observe that GABA-modulating anesthetics do not induce thalamocortical mediated frontal alpha coherence until 10-12 months of age. Using a small cohort of infants (n = 23) with EEG before and during GABA-modulating anesthesia, we provide preliminary evidence that infants with a low beta peak have higher anesthesia-induced alpha coherence compared to those without a low beta peak.
(© 2024. The Author(s).)
Databáze: MEDLINE
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