Combined detection of serum EFNA1 and MMP13 as diagnostic biomarker for gastric cancer.

Autor: Chu LY; Department of Pathology, Medical College of Jiaying University, No. 146 Huangtang Road, Meizhou, China.; Department of Clinical Laboratory Medicine, Esophageal Cancer Prevention and Control Research Center, the Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou, China.; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, China.; Guangdong Esophageal Cancer Institute, The Cancer Hospital of Shantou University Medical College, Shantou, China., Wu FC; Department of Head and Neck Surgery, Esophageal Cancer Prevention and Control Research Center, The Cancer Hospital of Shantou University Medical College, Shantou, China., Guo HP; Department of Radiation Oncology, Esophageal Cancer Prevention and Control Research Center, The Cancer Hospital of Shantou University Medical College, Shantou, China., Xie JJ; Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, China., Qu QQ; Department of Clinical Laboratory Medicine, Esophageal Cancer Prevention and Control Research Center, the Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou, China.; Guangdong Esophageal Cancer Institute, The Cancer Hospital of Shantou University Medical College, Shantou, China., Li XH; Department of Clinical Laboratory Medicine, Esophageal Cancer Prevention and Control Research Center, the Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou, China.; Guangdong Esophageal Cancer Institute, The Cancer Hospital of Shantou University Medical College, Shantou, China., Xu YW; Department of Clinical Laboratory Medicine, Esophageal Cancer Prevention and Control Research Center, the Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou, China. yiwei512@126.com.; Guangdong Esophageal Cancer Institute, The Cancer Hospital of Shantou University Medical College, Shantou, China. yiwei512@126.com., Peng YH; Department of Clinical Laboratory Medicine, Esophageal Cancer Prevention and Control Research Center, the Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou, China. pengyuhui666@163.com.; Guangdong Esophageal Cancer Institute, The Cancer Hospital of Shantou University Medical College, Shantou, China. pengyuhui666@163.com., Qiu B; Department of Pathology, Medical College of Jiaying University, No. 146 Huangtang Road, Meizhou, China. 1746088787@qq.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jul 10; Vol. 14 (1), pp. 15957. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1038/s41598-024-65839-y
Abstrakt: We previously identified that serum EFNA1 and MMP13 were potential biomarker for early detection of esophageal squamous cell carcinoma. In this study, our aim is to explore the diagnostic value of serum EFNA1 and MMP13 for gastric cancer. We used enzyme-linked immunosorbent assay (ELISA) to detect the expression levels of serum EFNA1 and MMP13 in 210 GCs and 223 normal controls. The diagnostic value of EFNA1 and MMP13 was evaluated in an independent cohorts of GC patients and normal controls (n = 238 and 195, respectively). Receiver operating characteristics were used to calculate diagnostic accuracy. In training and validation cohorts, serum EFNA1 and MMP13 levels in the GC groups were significantly higher than those in the normal controls (P < 0.001). The area under the curve (AUC) of the combined detection of serum EFNA1 and MMP13 for GC was improved (0.794), compared with single biomarker used. Similar results were observed in the validation cohort. Importantly, the combined measurement of serum EFNA1 and MMP13 to detect early-stage GC also had acceptable diagnostic accuracy in training and validation cohort. Combined detection of serum EFNA1 and MMP13 could help identify early-stage GC, suggesting that it may be a promising tool for the early detection of GC.
(© 2024. The Author(s).)
Databáze: MEDLINE
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