Serum Mac-2 binding protein glycosylation isomer dynamics in patients achieving sustained virologic response for hepatitis C virus.

Autor: Chang YP; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Liu CH; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Douliou, Taiwan., Huang CB; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lee JY; Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin Branch, Douliou, Taiwan., Liu CJ; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Su TH; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan., Huang SC; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital Bei-Hu Branch, Taipei, Taiwan., Tseng TC; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan., Chen PJ; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Kao JH; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
Jazyk: angličtina
Zdroj: Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2024 Nov; Vol. 39 (11), pp. 2439-2446. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1111/jgh.16680
Abstrakt: Background and Aim: Understanding the dynamics of serum Mac-2 binding protein glycosylation isomer (M2BPGi) remains pivotal for hepatitis C virus (HCV) patients' post-sustained virologic response (SVR 12 ) through direct-acting antivirals (DAAs).
Methods: We compared areas under receiver operating characteristic curves (AUROCs) of M2BPGi, FIB-4, and APRI and assess M2BPGi cutoff levels in predicting fibrosis stages of ≥F3 and F4 utilizing transient elastography in 638 patients. Variations in M2BPGi levels from pretreatment to SVR 12 and their association with pretreatment alanine transaminase (ALT) levels and fibrosis stage were investigated.
Results: The AUROCs of M2BPGi were comparable to FIB-4 in predicting ≥F3 (0.914 vs 0.902, P = 0.48) and F4 (0.947 vs 0.915, P = 0.05) but were superior to APRI in predicting ≥F3 (0.914 vs 0.851, P = 0.001) and F4 (0.947 vs 0.857, P < 0.001). Using M2BPGi cutoff values of 2.83 and 3.98, fibrosis stages of ≥F3 and F4 were confirmed with a positive likelihood ratio ≥10. The median M2BPGi change was -0.55. Patients with ALT levels ≥5 times ULN or ≥F3 demonstrated more pronounced median decreases in M2BPGi level compared to those with ALT levels 2-5 times ULN and <2 times ULN (-0.97 vs -0.68 and -0.44; P < 0.001) or with < F3 (-1.52 vs -0.44; P < 0.001).
Conclusions: Serum M2BPGi is a reliable marker for advanced hepatic fibrosis. Following viral clearance, there is a notable M2BPGi decrease, with the extent of reduction influenced by ALT levels and fibrosis stage.
(© 2024 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE