Application of plant-derived products as adjuvants for immune activation and vaccine development.

Autor: Zou M; Institute of Innovation and Applied Research, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China., Lei C; Institute of Innovation and Applied Research, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China., Huang D; Institute of Innovation and Applied Research, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China., Liu L; Institute of Innovation and Applied Research, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China., Han Y; The First Hospital, Hunan University of Chinese Medicine, Hunan Province, Changsha 410007, China. Electronic address: hanyuanshan@hnucm.edu.cn.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Nov 14; Vol. 42 (25), pp. 126115. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1016/j.vaccine.2024.07.016
Abstrakt: Vaccines are one of the most important means to prevent and control the epidemic of infectious diseases. Commercial vaccines not only include corresponding antigens, but also need vaccine adjuvants. Immune adjuvants play an increasingly important role in the research, development and manufacture of vaccines. Adjuvants combined with antigens can improve the stability, safety and immune efficiency of vaccines. Some substances that can enhance the immune response have been found in nature(mainly plants) and used as adjuvants in vaccines to improve the immune effect of vaccines. These plant-derived immune adjuvants often have the advantages of low toxicity, high stability, low price, etc., providing more possibilities for vaccine development. We summarized and analyzed the advantages, application research, particulate delivery systems, existing problems and future research focus of botanical adjuvant. It is hoped to provide new ideas for the research and development of immune adjuvants in the future.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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