Associations of cannabis use and body mass index-The Coronary Artery Risk Development in Young Adults (CARDIA) study.

Autor: Jakob J; Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, Bern 3012, Switzerland; Department of Paediatrics, University Hospital Bern, Inselspital, Bern, Switzerland. Electronic address: julian.jakob@unibe.ch., Schwerdtel F; Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, Bern 3012, Switzerland., Sidney S; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Rodondi N; Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, Bern 3012, Switzerland; Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland., Pletcher MJ; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Reis JP; National Heart, Lung, and Blood Institute, Bethesda, USA., Muniyappa R; Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, USA., Clair C; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland., Tal K; Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, Bern 3012, Switzerland., Bancks MP; Department of Epidemiology & Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Rana JS; Department of Cardiology, Kaiser Permanente Northern California, Oakland, CA, USA., Collet TH; Service of Endocrinology, Diabetology, Nutrition and Therapeutic Education, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland; Diabetes Centre, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Auer R; Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, Bern 3012, Switzerland; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Jazyk: angličtina
Zdroj: European journal of internal medicine [Eur J Intern Med] 2024 Nov; Vol. 129, pp. 41-47. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1016/j.ejim.2024.07.007
Abstrakt: Background: With increasing use of cannabis, we need to know if cannabis use and Body Mass Index (BMI) are associated.
Methods: The Coronary Artery Risk Development in Young Adults Study followed Black and White adults over 30 years with assessments every 2 to 5 years in four centers in the USA. We assessed self-reported current and computed cumulative cannabis exposure at every visit, and studied associations with BMI, adjusted for relevant covariables in mixed longitudinal models. We also applied marginal structural models (MSM) accounting for the probability of having stopped cannabis over the last 5 years.
Results: At the Year 30 visit, 1,912 (58 %) identified as women and 1,600 (48 %) as Black, mean age was 56 (SD 2) years. While 2,849 (85 %) had ever used cannabis, 479 (14 %) currently used cannabis. Overall, participants contributed to 35,882 individual visits over 30 years. In multivariable adjusted models, mean BMI was significantly lower in daily cannabis users (26.6 kg/m 2 , 95 %CI 26.3 to 27.0) than in participants without current use (27.7 kg/m 2 , 95 %CI 27.5 to 27.9, p < 0.001). Cumulative cannabis use was not associated with BMI. The MSM showed no change in BMI when stopping cannabis use over a 5-year period (β=0.2 kg/m 2 total, 95 %CI -0.2 to 0.6).
Conclusions: Current cannabis use was associated with lower BMI, but cumulative cannabis use and cessation were not. This suggests that recreational cannabis use may not lead to clinically relevant changes in BMI and that the association between current cannabis use and lower BMI is likely due to residual confounding.
Competing Interests: Declaration of competing interest None reported. All authors had access to the data.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: