Chlordiazepoxide reduces anxiety-like behavior in the adolescent mouse elevated plus maze: A pharmacological validation study.

Autor: Themann A; Department of Psychology, The University of Texas at El Paso, El Paso, TX 79968, USA., Rodriguez M; Department of Psychology, The University of Texas at El Paso, El Paso, TX 79968, USA., Reyes-Arce J; Department of Psychology, The University of Texas at El Paso, El Paso, TX 79968, USA., Iñiguez SD; Department of Psychology, The University of Texas at El Paso, El Paso, TX 79968, USA. Electronic address: sdiniguez@utep.edu.
Jazyk: angličtina
Zdroj: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2024 Sep; Vol. 242, pp. 173819. Date of Electronic Publication: 2024 Jul 08.
DOI: 10.1016/j.pbb.2024.173819
Abstrakt: This report evaluates the effects of chlordiazepoxide, a benzodiazepine commonly prescribed to manage anxiety-related disorders in adolescent/pediatric populations, on elevated plus maze (EPM) performance in juvenile mice. This approach was taken because chlordiazepoxide produces anxiolytic-like effects in multiple models in adult rodents, however, less is known about the behavioral effects of this benzodiazepine in juveniles. Thus, we administered a single intraperitoneal injection of chlordiazepoxide (0, 5, or 10 mg/kg) to postnatal day 35 male C57BL/6 mice. Thirty minutes later, mice were allowed to explore the EPM for 5-min. We found that chlordiazepoxide-treated mice (5 and 10 mg/kg) spent more time exploring the open arms of the EPM. No differences in velocity (cm/s) or distance traveled (cm) were observed between the groups. These results indicate that chlordiazepoxide induces anxiolytic-related behavior in adolescent male mice.
Competing Interests: Declaration of competing interest The authors declare no financial, or non-financial, conflict of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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