Carcinoid crisis: The challenge is still there.

Autor: Guerrero-Pérez F; Department of Endocrinology, Bellvitge University Hospital, Barcelona, Spain; Biomedical Research Institute of Bellvitge (IDIBELL), Barcelona, Spain. Electronic address: fguerrerop@bellvitgehospital.cat., Peiró I; Clinical Nutrition Unit, Catalan Institute of Oncology, Barcelona, Spain; Unit of Nutrition and Cancer-IDIBELL, Barcelona, Spain., Vercher-Conejero JL; Biomedical Research Institute of Bellvitge (IDIBELL), Barcelona, Spain; Department of Nuclear Medicine-PET Unit, Bellvitge University Hospital, Barcelona, Spain., Teulé A; Department of Oncology, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain., Villabona C; Department of Endocrinology, Bellvitge University Hospital, Barcelona, Spain; Biomedical Research Institute of Bellvitge (IDIBELL), Barcelona, Spain.
Jazyk: angličtina
Zdroj: Endocrinologia, diabetes y nutricion [Endocrinol Diabetes Nutr (Engl Ed)] 2024 Jun-Jul; Vol. 71 (6), pp. 263-270.
DOI: 10.1016/j.endien.2024.03.020
Abstrakt: Carcinoid crisis (CC) has classically been considered the extreme end of the spectrum of carcinoid syndrome (CS). However, this presumption and other aspects of CC remain poorly understood. Consequently, current clinical guidelines are based on a low quality of evidence. There is no standard definition of CC and its incidence is unknown. Patients with florid CS and elevated serotonin (or its derivatives) which develop CC have been reported during decades. Nevertheless, the hypothesis that CC is due to the sudden massive release of serotonin or other vasoactive substances is unproven. Many triggers of CC (surgery, anaesthesia, peptide receptor radionuclide therapy, tumour biopsy or liver-directed treatments) have been proposed. However, data from studies are heterogeneous and even contradictory. Finally, the role of octreotide in the prevention of CC has been questioned. Herein, we report a clinical case and perform a critical review of the evidence available today on this topic.
(Copyright © 2024 SEEN and SED. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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