Antimicrobial peptides: Opportunities and challenges in overcoming resistance.

Autor: Bucataru C; Alexandru I. Cuza University, Institute of Interdisciplinary Research, Department of Exact and Natural Sciences, Bulevardul Carol I, Nr.11, Iasi 700506, Romania., Ciobanasu C; Alexandru I. Cuza University, Institute of Interdisciplinary Research, Department of Exact and Natural Sciences, Bulevardul Carol I, Nr.11, Iasi 700506, Romania. Electronic address: vasilica.ciobanasu@uaic.ro.
Jazyk: angličtina
Zdroj: Microbiological research [Microbiol Res] 2024 Sep; Vol. 286, pp. 127822. Date of Electronic Publication: 2024 Jun 26.
DOI: 10.1016/j.micres.2024.127822
Abstrakt: Antibiotic resistance represents a global health threat, challenging the efficacy of traditional antimicrobial agents and necessitating innovative approaches to combat infectious diseases. Among these alternatives, antimicrobial peptides have emerged as promising candidates against resistant pathogens. Unlike traditional antibiotics with only one target, these peptides can use different mechanisms to destroy bacteria, with low toxicity to mammalian cells compared to many conventional antibiotics. Antimicrobial peptides (AMPs) have encouraging antibacterial properties and are currently employed in the clinical treatment of pathogen infection, cancer, wound healing, cosmetics, or biotechnology. This review summarizes the mechanisms of antimicrobial peptides against bacteria, discusses the mechanisms of drug resistance, the limitations and challenges of AMPs in peptide drug applications for combating drug-resistant bacterial infections, and strategies to enhance their capabilities.
Competing Interests: Declaration of Competing Interest The authors report no conflicts of interest in this work.
(Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.)
Databáze: MEDLINE
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