| Autor: |
Özgüldez HÖ; Stem Cell Chromatin Group, Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany; email: Aydan.Karslioglu@molgen.mpg.de., Bulut-Karslioğlu A; Stem Cell Chromatin Group, Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany; email: Aydan.Karslioglu@molgen.mpg.de. |
| Jazyk: |
angličtina |
| Zdroj: |
Annual review of cell and developmental biology [Annu Rev Cell Dev Biol] 2024 Oct; Vol. 40 (1), pp. 25-49. Date of Electronic Publication: 2024 Sep 21. |
| DOI: |
10.1146/annurev-cellbio-112122-022528 |
| Abstrakt: |
Life on Earth has been through numerous challenges over eons and, one way or another, has always triumphed. From mass extinctions to more daily plights to find food, unpredictability is everywhere. The adaptability of life-forms to ever-changing environments is the key that confers life's robustness. Adaptability has become synonymous with Darwinian evolution mediated by heritable genetic changes. The extreme gene-centric view, while being of central significance, at times has clouded our appreciation of the cell as a self-regulating entity informed of, and informing, the genetic data. An essential element that powers adaptability is the ability to regulate cell growth. In this review, we provide an extensive overview of growth regulation spanning species, tissues, and regulatory mechanisms. We aim to highlight the commonalities, as well as differences, of these phenomena and their molecular regulators. Finally, we curate open questions and areas for further exploration. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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