Characteristics and survival of advanced untreated hepatocellular carcinoma of non-viral etiology.

Autor: Ekanayaka SPN; Department of Surgery, Faculty of Medicine, Colombo North Center for Liver Disease, University of Kelaniya, Thalagolla Road, Ragama, Sri Lanka., Luke N; Department of Pharmacology, Faculty of Medicine, Colombo North Center for Liver Disease, University of Kelaniya, Ragama, Sri Lanka., Thilakarathne SB; Department of Surgery, Faculty of Medicine, Colombo North Center for Liver Disease, University of Kelaniya, Thalagolla Road, Ragama, Sri Lanka., Dassanayake A; Department of Pharmacology, Faculty of Medicine, Colombo North Center for Liver Disease, University of Kelaniya, Ragama, Sri Lanka., Gunetilleke MB; Department of Surgery, Faculty of Medicine, Colombo North Center for Liver Disease, University of Kelaniya, Thalagolla Road, Ragama, Sri Lanka., Niriella MA; Department of Surgery, Faculty of Medicine, Colombo North Center for Liver Disease, University of Kelaniya, Thalagolla Road, Ragama, Sri Lanka., Siriwardana RC; Department of Surgery, Faculty of Medicine, Colombo North Center for Liver Disease, University of Kelaniya, Thalagolla Road, Ragama, Sri Lanka. rohansiriwardana@yahoo.com.
Jazyk: angličtina
Zdroj: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology [Indian J Gastroenterol] 2024 Jul 10. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1007/s12664-024-01636-9
Abstrakt: Introduction and Objectives: Hepatocellular carcinoma (HCC) is an aggressive tumor and presents late. The underlying etiology of HCC is changing rapidly. HCC in Sri Lanka is unique due to its predominant non-viral etiology (nvHCC) but lacks survival data.
Method: Data was collected from patients who presented with HCC from 2011 to 2018. There were 560/568 (98.6%) nvHCC. The patients who were not candidates for tumor-specific treatment (149/560 [26.7%]) were selected. Population characteristics, demographic data, tumor characteristics, survival and factors affecting survival were analyzed.
Results: The median age was 64 years (range 30-88) and 86% (n = 129) were males. As many as 124 (83%) were cirrhotic. The overall performance score was 80%. Nearly 21/124 tumors were detected in cirrhotic screening. Tumors were single nodular in 32 (21%), up to three nodules in 28 (18%), more than three nodules in 33 (22%) and diffusely infiltrating in 56 (37%). The major venous invasions were present in 78 (52.3%). Extra-hepatic tumor spread was seen in 19 (12.7%) (lungs 13 [72.2%], bones 2 [11.1%]). The median survival of patients receiving palliative care was three months (1-43 months). Tumor size and cirrhotic status were significant predictors in univariate analysis.
Conclusion: A quarter of nvHCCs were not amenable to treatment at presentation as they had dismal survival.
Clinical Trial Registry Number: P/126/09/2021.
(© 2024. Indian Society of Gastroenterology.)
Databáze: MEDLINE
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