Aronia Melanocarpa Elliot Anthocyanins Inhibits Alcoholic Liver Disease by Activation of α7nAChR.

Autor: Wei J; School of Life Science, Liaoning University, Chongshan Middle Road 66, Huanggu District, Shenyang, Liaoning, 110036, China. J.Wei2015@hotmail.com., Tang X; School of Life Science, Liaoning University, Chongshan Middle Road 66, Huanggu District, Shenyang, Liaoning, 110036, China., He Y; School of Life Science, Liaoning University, Chongshan Middle Road 66, Huanggu District, Shenyang, Liaoning, 110036, China., Peng Z; School of Life Science, Liaoning University, Chongshan Middle Road 66, Huanggu District, Shenyang, Liaoning, 110036, China., Liu H; School of Life Science, Liaoning University, Chongshan Middle Road 66, Huanggu District, Shenyang, Liaoning, 110036, China., He Y; School of Life Science, Liaoning University, Chongshan Middle Road 66, Huanggu District, Shenyang, Liaoning, 110036, China., Gao J; Liaoning Academy of Forestry, Yalujiang Street 12, Huanggu District, Shenyang, 110032, China. gaojun200212@163.com.
Jazyk: angličtina
Zdroj: Plant foods for human nutrition (Dordrecht, Netherlands) [Plant Foods Hum Nutr] 2024 Dec; Vol. 79 (4), pp. 779-794. Date of Electronic Publication: 2024 Jul 10.
DOI: 10.1007/s11130-024-01213-7
Abstrakt: The study wanted to explore the preventative effects of Aornia melanocarpa Elliot anthocyanins (AMA) to Alcoholic liver disease (ALD) by bioinformatics prediction and experimental verification. We founded 419 differentially expressed genes (DEGs) in GSE28619 related to ALD from GEO database, COL1A1 was selected by the core gene module construction and molecular docking. Mice were treated by intragastric administration of gradient 50% ethanol, AMA alleviated liver injury by ALD and ameliorated the model's body weight, lessened the liver inflammation according to histopathological evaluation, increased serum liver biochemical index (AST, ALT, TC, TG and LDL-C) and decreased HDL-C, reversed the expression of enzymes (ALDH and GSH-PX), decreased cytokines expression (Ki67, TNF-α and IL-6), reversed the expression of α7nAChR and collagen I, downregulated the PI3K-Akt pathway and Keap1/HO-1 pathway (p-PI3K, PI3K, p-Akt, Akt, Keap1, Nrf2, HO-1,GSK-3β and Bcl-2), indicated that α7nAChR and collagen I may be the AMA action targets.
Competing Interests: Declarations All animal experiments adhere to the ARRIVE guidelines Ethical approval This article does not contain any studies with human participants performed by any of the authors. Competing Interests The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: