Cutting Edge: Redundant Roles for MHC Class II-, CD1d-, and MR1-restricted T Cells in Clearing Bartonella Infection.

Autor:	Siewert LK; Biozentrum, University of Basel, Basel, Switzerland.; Division of Experimental Virology, Department Biomedicine-Haus Petersplatz, University of Basel, Basel, Switzerland., Fromm K; Biozentrum, University of Basel, Basel, Switzerland., Dehio C; Biozentrum, University of Basel, Basel, Switzerland., Pinschewer DD; Division of Experimental Virology, Department Biomedicine-Haus Petersplatz, University of Basel, Basel, Switzerland.
Jazyk:	angličtina
Zdroj:	Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Sep 01; Vol. 213 (5), pp. 553-558.
DOI:	10.4049/jimmunol.2400045
Abstrakt:	The importance of unconventional T cells for mucosal immunity is firmly established but for systemic bacterial infection remains less well defined. In this study, we explored the role of various T cell subsets in murine Bartonella infection, which establishes persistent bacteremia unless controlled by antibacterial Abs. We found that αβ T cells are essential for Ab production against and clearance of B. taylorii, whereas MHC class I (MHC-I)- or MHC class II (MHC-II)-deficient mice eliminated B. taylorii infection with normal kinetics. Similarly, animals lacking either CD1d or MR1 suppressed bacteremia with normal kinetics. Interestingly, mice with a combined deficiency of either MHC-II and CD1d or MHC-II and MR1 failed to clear the infection, indicating that the combination of CD1d- and MR1-restricted T cells can compensate for the lack of MHC-II in this model. Our data document a previously underappreciated contribution of unconventional T cells to the control of systemic bacterial infection, supposedly as helper cells for antibacterial Ab production. (Copyright © 2024 by The American Association of Immunologists, Inc.)
Databáze:	MEDLINE
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