Diagnosing sucrase-isomaltase deficiency: a comparison of a 13 C-sucrose breath test and a duodenal enzyme assay.
| Autor: | Dale HF; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.; Department of Clinical Support, Lovisenberg Diaconal Hospital, Oslo, Norway., Hagen M; Faculty of Health Science, Oslo Metropolitan University, Oslo, Norway.; Department of Research, Lovisenberg Diaconal Hospital, Oslo, Norway., Deb C; Gastroenterology Translational Research Division, Arnold Palmer Hospital, Specialty Diagnostic Laboratory, Orlando, USA., Skar V; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway., Valeur J; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. |
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| Jazyk: | angličtina |
| Zdroj: | Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 2024 Jul; Vol. 84 (4), pp. 268-272. Date of Electronic Publication: 2024 Jul 10. |
| DOI: | 10.1080/00365513.2024.2377960 |
| Abstrakt: | Background: Reduced activity of the sucrase-isomaltase (SI) enzyme can cause gastrointestinal symptoms. Biochemical measurement of SI activity in small intestinal biopsies is presently considered the gold standard for the diagnosis of SI deficiency, but this invasive test is not suitable as a routine diagnostic tool. Aim: To evaluate a 13 C-sucrose-breath test ( 13 CSBT) as a diagnostic tool for SI deficiency in an adult population. Methods: 13 CSBT results were compared to sucrase activity measured in duodenal biopsies. Results: Forty patients with gastrointestinal symptoms were included in the study, 4 of whom had celiac disease and the rest ( n = 36) had normal histological findings. Nine patients (22.5%) had low sucrase activity measured using duodenal biopsies. No correlation was observed between enzymatic sucrase activity and the 13 CSBT results. The 13 CSBT-curves for the celiac patients versus patients with normal duodenal histology demonstrated that the patients with celiac disease were within the lower range of the distribution. Conclusion: We observed a mismatch between the 13 CSBT results and the biochemically measured sucrase activity, suggesting that SI activity is not uniformly distributed throughout the small intestines. This methodological discrepancy should be acknowledged when diagnosing SI deficiency. |
| Databáze: | MEDLINE |
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