Driving forces of continuing evolution of rotaviruses.
| Autor: | Hakim MS; Postgraduate School of Molecular Medicine, Erasmus MC-University Medical Center, Rotterdam 3015GD, Netherlands.; Viral Infection Working Group, International Society of Antimicrobial Chemotherapy, London EC4R 9AN, United Kingdom., Gazali FM; Master Program in Biotechnology, Postgraduate School, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia., Widyaningsih SA; Master of Medical Sciences in Clinical Investigation, Harvard Medical School, Boston, MA 02115, United States., Parvez MK; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia. mohkhalid@ksu.edu.sa. |
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| Jazyk: | angličtina |
| Zdroj: | World journal of virology [World J Virol] 2024 Jun 25; Vol. 13 (2), pp. 93774. |
| DOI: | 10.5501/wjv.v13.i2.93774 |
| Abstrakt: | Rotaviruses are non-enveloped double-stranded RNA virus that causes acute diarrheal diseases in children (< 5 years). More than 90% of the global rotavirus infection in humans was caused by Rotavirus group A. Rotavirus infection has caused more than 200000 deaths annually and predominantly occurs in the low-income countries. Rotavirus evolution is indicated by the strain dynamics or the emergence of the unprecedented strain. The major factors that drive the rotavirus evolution include the genetic shift that is caused by the reassortment mechanism, either in the intra- or the inter-genogroup. However, other factors are also known to have an impact on rotavirus evolution. This review discusses the structure and types, epidemiology, and evolution of rotaviruses. This article also reviews other supplemental factors of rotavirus evolution, such as genetic reassortment, mutation rate, glycan specificity, vaccine introduction, the host immune responses, and antiviral drugs. Competing Interests: Conflict-of-interest statement: All authors declare no conflict of interest. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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